Cover Image

Total Exposure Health : An Introduction.

Bibliographic Details
Main Author: Phillips, Kirk A.
Other Authors: Yamamoto, Dirk P., Racz, LeeAnn.
Format: eBook
Language:English
Published: Milton : Taylor & Francis Group, 2020.
Series:Environmental and Occupational Health Ser.
Subjects:
Health risk assessment.
Electronic books.
Online Access:View fulltext via EzAccess
Table of Contents:
  • Cover
  • Half Title
  • Series Page
  • Title Page
  • Copyright Page
  • Dedication
  • Table of Contents
  • Foreword
  • Preface
  • Acknowledgments
  • Editors
  • Contributors
  • Section I: Overview and Fundamentals
  • Chapter 1 Total Exposure Health: An Exposure Science Framework for the Fourth Industrial Age
  • 1.1 Origins of Total Exposure Health
  • 1.1.2 The Steadfast Practice of Industrial Hygiene
  • 1.1.3 Exposures and Exposed Populations Are Decreasing
  • 1.1.4 Sensors Are (Almost) Ubiquitous
  • 1.1.5 Expanded Knowledge of Disease, Mechanisms of Disease, and Genetics
  • 1.2 Aims of Total Exposure Health
  • 1.3 The Totals Explained
  • 1.3.1 Total Worker Health[sup(®)]
  • 1.3.2 Total Worker Exposure (TWE)
  • 1.3.3 Total Exposure Health(TEH)
  • 1.4 TEH Exposures of Concern
  • 1.4.1 Occupational
  • 1.4.2 Environment
  • 1.4.3 Lifestyle
  • 1.4.4 Clinical
  • 1.5 TEH Exposure Data Sources
  • 1.5.1 Workplace IH
  • 1.5.2 Environmental and Community Health
  • 1.5.3 Personal Environmental Exposure Sensors and the Internet of Things
  • 1.6 Healthcare Is Changing-Personalized Healthcare
  • 1.6.1 Patient Centric
  • 1.6.2 Exposure Curves: Where Does an Individual Fit In
  • 1.7 The Fourth Industrial Revolution and TEH
  • 1.7.1 Computational Toxicology
  • 1.7.2 Genetic Expression
  • 1.8 Novel Controls Additions to the Hierarchy
  • 1.8.1 Individual Exposure Health Risk Profile (IEHRP)
  • 1.8.2 Preexposure Prophylaxis
  • 1.8.3 Self-Limiting Exposures
  • 1.8.4 Nonoccupational PPE/Increased Occupational PPE
  • 1.8.5 Durable Medical Equipment
  • 1.8.6 Blood Chemistry Tracking
  • 1.9 TEH-Bringing It All Together
  • References
  • Chapter 2 The Individual Exposure Health Risk Profile (IEHRP)- Developing a Risk Profile Tool beyond Dose Response
  • 2.1 Introduction
  • 2.2 Total Exposure Health (TEH)
  • 2.3 Noise Exposure Demonstration Project (NEDP).
  • 2.4 Individual Exposure Health Risk Profile (IEHRP)
  • 2.5 Conclusion
  • References
  • Chapter 3 In Pursuit of Total Exposure Health: Leveraging Exposure Science, the Omics, and Other Emerging Technologies
  • 3.1 Introduction
  • 3.2 Exposure Science: Key Principles Useful for Total Exposure Health
  • 3.3 High-Throughput Metabolomics in Total Exposure Health
  • 3.3.1 The Omics
  • 3.3.2 Metabolomics
  • 3.3.2.1 Targeted Metabolomics
  • 3.3.2.2 Untargeted Metabolomics
  • 3.3.3 Growth of Metabolomics
  • 3.4 The Human Microbiome as a Modifier of Personalized Exposures
  • 3.4.1 The Microbiome of a Baby
  • 3.4.2 The Gut Microbiome
  • 3.5 Pharmacokinetics
  • 3.5.1 Absorption, Distribution, Metabolism, and Excretion
  • 3.5.2 Physiologically Based Pharmacokinetic (PBPK) Modeling
  • 3.6 Conclusions
  • References
  • Chapter 4 Total Worker Health : Bridging Worker Exposure and Well-Being
  • 4.1 Introduction
  • 4.2 What Is TWH?
  • 4.2.1 Comparing the TWH Approach
  • 4.2.2 Issues Relevant to Advancing Worker Well-Being through Total Worker Health[sup(®)]
  • 4.2.3 What TWH Looks Like in Practice
  • 4.3 The 1st and 2nd International Symposia to Advance Total Worker Health[sup(®)]
  • 4.4 Advances in Research
  • 4.4.1 National Total Worker Health[sup(®)] Agenda
  • 4.4.2 Total Worker Health Research Methodology Workshop
  • 4.4.3 Worker Well-Being Framework
  • 4.4.4 Centers of Excellence for TWH
  • 4.5 Research to Practice
  • 4.5.1 Fundamentals of Total Worker Health[sup(®)] Approaches
  • 4.5.2 Hierarchy of Controls Applied to NIOSH Total Worker Health[sup(®)]
  • 4.6 Determining Overall Risk and Exposure for Worker Safety, Health, and Well-Being
  • 4.6.1 Cumulative Risk Assessment
  • 4.6.2 Total Exposure Health
  • 4.6.3 TWH, CRA, and TEH
  • 4.7 Partnership and Stakeholder Involvement
  • 4.7.1 NIOSH TWH Affiliates
  • 4.7.2 Collaborative Activities
  • 4.8 Conclusion.
  • References
  • Chapter 5 Industrial Hygiene: A Foundational Role in Total Exposure Health
  • 5.1 Introduction
  • 5.2 What Is Industrial Hygiene?
  • 5.2.1 Definition of Industrial Hygiene
  • 5.2.2 OSHA Compliance
  • 5.3 History of Industrial Hygiene
  • 5.3.1 Early Names in IH
  • 5.3.2 Academic Programs and ABET
  • 5.3.3 Professional Organizations
  • 5.3.3.1 American Conference of Governmental Industrial Hygienists (ACGIH[sup(®)])
  • 5.3.3.2 American Industrial Hygiene Association (AIHA[sup(®)])
  • 5.3.3.3 Board for Global EHS Credentialing (BGC[sup(®)])
  • 5.3.3.4 Occupational Safety and Health Administration (OSHA)
  • 5.3.3.5 National Institute for Occupational Safety and Health (NIOSH)
  • 5.4 Today's Industrial Hygiene
  • 5.4.1 Anticipation-Recognition-Evaluation-Control-Confirm
  • 5.4.1.1 Anticipation
  • 5.4.1.2 Recognition
  • 5.4.1.3 Evaluation
  • 5.4.1.4 Control
  • 5.4.1.5 Confirm
  • 5.4.2 Exposure Assessment: A Core Function of Industrial Hygiene
  • 5.4.2.1 Exposure Assessment-Defined
  • 5.4.2.2 Comprehensive Exposure Assessment-More than Compliance
  • 5.5 The Future of Industrial Hygiene and Total Exposure Health
  • 5.5.1 Industrial Hygienists: Ready for Total Exposure Health
  • 5.5.2 Challenges for Industrial Hygienists in Fulfilling TEH
  • References
  • Section II: Advances in Toxicology and the -Omics
  • Chapter 6 Personalizing Environmental Health for the Military-Striving for Precision
  • 6.1 The Need for Precision in Military Environmental Health
  • 6.2 From Past to Present: The Changing Landscape of Precision Medicine
  • 6.2.1 Technology and Medicine
  • 6.2.2 Genetics versus Genomics
  • 6.2.3 Genomics and the Overpromise of GWAS
  • 6.2.4 Sequencing and 'Omics' Technology Advancements
  • 6.2.5 The 'Great GWAS Do-over'?
  • 6.2.6 Incorporating the Changing Landscape of Genomics into the Clinic over Time.
  • 6.3 Precision beyond Genomics: Environment, Exposures, and Social Background
  • 6.3.1 Getting More Personal: The Microbiome as an Interface
  • 6.3.2 Models of Risk and Exposure
  • 6.3.3 Likelihood Ratio (LR)
  • 6.3.4 Social Determinants of Health (SDOH)
  • 6.4 Precision Medicine and Environmental Health for the Military
  • 6.4.1 The Million Veterans Program
  • 6.4.2 Ethical, Legal, and Social Issues (ELSI)
  • 6.5 Outlook
  • References
  • Chapter 7 In Silico Identification of Protein Targets for Chemical Neurotoxins Using ToxCast in Vitro Data and Read-Across within the QSAR Toolbox
  • 7.1 Introduction
  • 7.2 Materials and Methods
  • 7.2.1 ToxCast Compound Dataset
  • 7.2.2 Bioactivity Data Associated with Neurotoxicity
  • 7.2.3 Performance Evaluation
  • 7.2.4 Software
  • 7.3 Results and Discussion
  • 7.4 Conclusions
  • 7.5 Conflict of Interest
  • 7.6 Acknowledgments
  • References
  • Chapter 8 "Omics": An Introduction
  • 8.1 Introduction
  • 8.2 Genomics
  • 8.2.1 Sequencing Technologies
  • 8.2.2 Utility of Whole-Genome Sequence in Total Exposure Health
  • 8.3 Transcriptomics
  • 8.3.1 Analytic Methods for Transcriptomics
  • 8.3.2 Transcriptomics Role in TEH
  • 8.4 Epigenomics
  • 8.4.1 Measuring Epigenomic Marks
  • 8.4.2 The Epigenome in TEH
  • 8.5 Proteome
  • 8.5.1 Proteomics Methods
  • 8.5.2 Proteomics Utility in TEH
  • 8.6 Metabolome
  • 8.6.1 Metabolome Methods
  • 8.6.2 Metabolome in TEH
  • 8.7 Microbiome
  • 8.7.1 Enumerating the Microbiome
  • 8.7.2 Microbiome Relevance in TEH
  • 8.8 Pan-Omics in a TEH Model
  • References
  • Chapter 9 Silicone Wristbands and Wearables to Assess Chemical Exposures
  • 9.1 Personal Chemical Exposures
  • 9.2 Passive Sampling
  • 9.2.1 Passive Sampling Background
  • 9.2.2 Silicone Wristbands
  • 9.3 Silicone Wristband Characterization
  • 9.3.1 Wristband Advantages
  • 9.3.2 Chemical Uptake
  • 9.3.3 Wristband Data Applications.
  • 9.3.4 Silicone Wristband Limitations and Additional Considerations
  • 9.4 Laboratory Practices
  • 9.4.1 Wristband Preparation and Shipment
  • 9.4.2 Chemical Stability in Wristbands
  • 9.4.3 Chemical Extraction
  • 9.4.4 Chemical and Biological Analysis
  • 9.5 Human Research Ethics
  • 9.6 Silicone Wristband Applications
  • 9.6.1 Initial Field Applications
  • 9.6.2 Comparisons with Conventional Exposure Assessment Technologies
  • 9.6.3 Health Effects
  • 9.6.4 Additional Configurations of Silicone Wristbands
  • 9.7 Future Directions
  • 9.7.1 Chemical Mixtures
  • 9.7.2 Disaster-Related Exposures
  • 9.7.3 Behavioral Health Interventions
  • 9.7.4 Precision Health and Precision Prevention
  • Acknowledgments
  • Conflict of Interest
  • References
  • Chapter 10 Total Exposure Hearing Health Preservation
  • 10.1 Introduction
  • 10.2 Overview of Hearing Health
  • 10.3 Auditory and Non-Auditory Health Effects
  • 10.4 Exposure Lifetime
  • 10.5 Noise Type: Continuous and Impulse
  • 10.6 Non-Noise Exposures
  • 10.7 Genetics
  • 10.8 How Do I Measure Risk?
  • 10.9 How Do I Control Risk?
  • 10.10 Conclusion
  • References
  • Chapter 11 The Role of Noise Exposure as an Element of Total Exposure Health: Determination of 24-Hour Noise Exposure Profiles on U.S. Navy Aircraft Carriers
  • 11.1 Introduction
  • 11.2 Noise Exposure on U.S. Navy Aircraft Carriers
  • 11.3 Auditory Effects
  • 11.4 Non-Auditory Effects
  • 11.5 Regulation
  • 11.6 24-Hour Noise Exposure Aboard U.S. Navy Aircraft Carriers (Schaal et al., 2019c)
  • 11.7 Characterization of Extended Shift Noise Exposures among Low Noise Hazard U.S. Navy Aircraft Carrier Support Personnel (Schaal et al., 2019a)
  • 11.8 Noise Characterization of "Effective Quiet" Areas on a U.S. Navy Aircraft Carrier (Schaal et al., 2019d)
  • 11.9 Sound Level Measurements in Berthing Areas of an Aircraft Carrier (Schaal et al., 2019b).
  • 11.10 Discussion.

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