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|a Silverthorn, Dee Unglaub.
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|a Human Physiology.
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|a 8th ed.
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|a Harlow, United Kingdom :
|b Pearson Education Limited,
|c 2018.
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|c ©2019.
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|a 1 online resource (983 pages)
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|a text
|b txt
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|a Front Cover -- Contents in Brief -- Title Page -- Copyright Page -- About the Author -- Dedication -- Acknowledgments -- Contents -- UNIT 1 Basic Cell Processes: Integration and Coordination -- Chapter 1: Introduction to Physiology -- Physiology Is an Integrative Science -- RUNNING PROBLEM What to Believe? -- Emerging Concepts The Changing World of Omics -- Function and Mechanism -- Themes in Physiology -- Focus on . . . Mapping -- Theme 1: Structure and Function Are Closely Related -- Theme 2: Living Organisms Need Energy -- Theme 3: Information Flow Coordinates Body Functions -- Theme 4: Homeostasis Maintains Internal Stability -- Homeostasis -- What Is the Body's Internal Environment? -- Homeostasis Depends on Mass Balance -- Excretion Clears Substances from the Body -- Homeostasis Does Not Mean Equilibrium -- Control Systems and Homeostasis -- Local Control Is Restricted to a Tissue -- Reflex Control Uses Long‐Distance Signaling -- Response Loops Begin with a Stimulus -- Feedback Loops Modulate the Response Loop -- Negative Feedback Loops Are Homeostatic -- Positive Feedback Loops Are Not Homeostatic -- Feedforward Control Allows the Body to Anticipate Change -- Biological Rhythms Result from Changes in a Setpoint -- The Science of Physiology -- Good Scientific Experiments Must Be Carefully Designed -- Focus on . . . Graphing -- The Results of Human Experiments Can Be Difficult to Interpret -- CHAPTER SUMMARY -- REVIEW QUESTIONS -- Chapter 2: Molecular Interactions -- RUNNING PROBLEM Chromium Supplements -- Molecules and Bonds -- Most Biomolecules Contain Carbon, Hydrogen, and Oxygen -- Electrons Have Four Important Biological Roles -- Covalent Bonds between Atoms Create Molecules -- Noncovalent Bonds Facilitate Reversible Interactions -- Noncovalent Interactions -- Hydrophilic Interactions Create Biological Solutions.
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|a Molecular Shape Is Related to Molecular Function -- Hydrogen Ions in Solution Can Alter Molecular Shape -- Protein Interactions -- Proteins Are Selective about the Molecules They Bind -- Protein‐Binding Reactions Are Reversible -- Binding Reactions Obey the Law of Mass Action -- The Dissociation Constant Indicates Affinity -- Multiple Factors Alter Protein Binding -- The Body Regulates the Amount of Protein in Cells -- Reaction Rate Can Reach a Maximum -- CHAPTER SUMMARY -- REVIEW QUESTIONS -- Chapter 3: Compartmentation: Cells and Tissues -- RUNNING PROBLEM Pap Tests Save Lives -- Functional Compartments of the Body -- The Lumens of Some Organs Are Outside the Body -- Functionally, the Body Has Three Fluid Compartments -- Biological Membranes -- The Cell Membrane Separates Cell from Environment -- Membranes Are Mostly Lipid and Protein -- Membrane Lipids Create a Hydrophobic Barrier -- Membrane Proteins May Be Loosely or Tightly Bound to the Membrane -- Membrane Carbohydrates Attach to Both Lipids and Proteins -- Intracellular Compartments -- Cells Are Divided into Compartments -- The Cytoplasm Includes Cytosol, Inclusions, Fibers, and Organelles -- Inclusions Are in Direct Contact with the Cytosol -- Cytoplasmic Protein Fibers Come in Three Sizes -- Microtubules Form Centrioles, Cilia, and Flagella -- Emerging Concepts Single Cilia Are Sensors -- The Cytoskeleton Is a Changeable Scaffold -- Motor Proteins Create Movement -- Organelles Create Compartments for Specialized Functions -- The Nucleus Is the Cell's Control Center -- Tissues of the Body -- Extracellular Matrix Has Many Functions -- Cell Junctions Hold Cells Together to Form Tissues -- Epithelia Provide Protection and Regulate Exchange -- Connective Tissues Provide Support and Barriers -- Muscle and Neural Tissues Are Excitable -- Tissue Remodeling -- Apoptosis Is a Tidy Form of Cell Death.
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|a Stem Cells Can Create New Specialized Cells -- Emerging Concepts Induced Pluripotent Stems Cells -- Focus on . . . The Skin -- Organs -- CHAPTER SUMMARY -- REVIEW QUESTIONS -- Chapter 4: Energy and Cellular Metabolism -- RUNNING PROBLEM Tay‐Sachs Disease: A Deadly Inheritance -- Energy in Biological Systems -- Energy Is Used to Perform Work -- Energy Comes in Two Forms: Kinetic and Potential -- Energy Can Be Converted from One Form to Another -- Thermodynamics Is the Study of Energy Use -- Chemical Reactions -- Energy Is Transferred between Molecules during Reactions -- Activation Energy Gets Reactions Started -- Energy Is Trapped or Released during Reactions -- Net Free Energy Change Determines Reaction Reversibility -- Enzymes -- Enzymes Are Proteins -- Reaction Rates Are Variable -- Enzymes May Be Activated, Inactivated, or Modulated -- Enzymes Lower Activation Energy of Reactions -- Enzymatic Reactions Can Be Categorized -- Metabolism -- Cells Regulate Their Metabolic Pathways -- Catabolic Pathways Produce ATP -- One Glucose Molecule Can Yield 30-32 ATP -- Anaerobic Metabolism Makes Two ATP -- Proteins Are the Key to Cell Function -- DNA Guides the Synthesis of RNA -- Alternative Splicing Creates Multiple Proteins from One DNA Sequence -- mRNA Translation Links Amino Acids -- Emerging Concepts Purple Petunias and RNAi -- Protein Sorting Directs Proteins to Their Destination -- Proteins Undergo Posttranslational Modification -- CHAPTER SUMMARY -- REVIEW QUESTIONS -- Chapter 5: Membrane Dynamics -- RUNNING PROBLEM Cystic Fibrosis -- Homeostasis Does Not Mean Equilibrium -- Osmosis and Tonicity -- The Body Is Mostly Water -- The Body Is in Osmotic Equilibrium -- Osmolarity Describes the Number of Particles in Solution -- Tonicity Describes the Volume Change of a Cell -- Transport Processes -- Cell Membranes Are Selectively Permeable -- Diffusion.
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|a Lipophilic Molecules Cross Membranes by Simple Diffusion -- Protein‐Mediated Transport -- Membrane Proteins Have Four Major Functions -- Channel Proteins Form Open, Water‐Filled Passageways -- Carrier Proteins Change Conformation to Move Molecules -- Facilitated Diffusion Uses Carrier Proteins -- Active Transport Moves Substances against Their ‐Concentration Gradients -- Carrier‐Mediated Transport Exhibits Specificity, Competition, and Saturation -- Vesicular Transport -- Phagocytosis Creates Vesicles Using the Cytoskeleton -- Endocytosis Creates Smaller Vesicles -- CLINICAL FOCUS LDL: The Lethal Lipoprotein -- Exocytosis Releases Molecules Too Large for Transport Proteins -- Epithelial Transport -- Epithelial Transport May Be Paracellular or Transcellular -- Transcellular Transport of Glucose Uses Membrane Proteins -- Transcytosis Uses Vesicles to Cross an Epithelium -- The Resting Membrane Potential -- Electricity Review -- The Cell Membrane Enables Separation of Electrical Charge in the Body -- All Living Cells Have a Membrane Potential -- The Resting Membrane Potential Is Due Mostly to Potassium -- Changes in Ion Permeability Change the Membrane Potential -- Integrated Membrane Processes: Insulin Secretion -- CHAPTER SUMMARY -- REVIEW QUESTIONS -- Chapter 6: Communication, Integration, and Homeostasis -- Cell‐to‐Cell Communication -- RUNNING PROBLEM Diabetes Mellitus: A Growing Epidemic -- Gap Junctions Create Cytoplasmic Bridges -- Contact‐Dependent Signals Require Cell‐to‐Cell Contact -- Local Communication Uses Paracrine and Autocrine Signals -- Long‐Distance Communication May Be Electrical or Chemical -- Cytokines May Act as Both Local and Long‐Distance Signals -- Signal Pathways -- Receptor Proteins Are Located Inside the Cell or on the Cell Membrane -- Membrane Proteins Facilitate Signal Transduction.
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|a The Most Rapid Signal Pathways Change Ion Flow through Channels -- Most Signal Transduction Uses G Proteins -- Many Lipophobic Hormones Use GPCR‐cAMP Pathways -- G Protein‐Coupled Receptors Also Use Lipid‐Derived Second Messengers -- Catalytic Receptors Have Enzyme Activity -- Integrin Receptors Transfer Information from the Extracellular Matrix -- Novel Signal Molecules -- Calcium Is an Important Intracellular Signal -- Gases Are Ephemeral Signal Molecules -- BIOTECHNOLOGY Calcium Signals Glow in the Dark -- CLINICAL FOCUS From Dynamite to Medicine -- Some Lipids Are Important Paracrine Signals -- Modulation of Signal Pathways -- Receptors Exhibit Saturation, Specificity, and Competition -- One Ligand May Have Multiple Receptors -- Up and Down‐Regulation Enable Cells to Modulate Responses -- Cells Must Be Able to Terminate Signal Pathways -- Many Diseases and Drugs Target the Proteins of Signal Transduction -- Homeostatic Reflex Pathways -- Cannon's Postulates Describe Regulated Variables and ‐Control Systems -- Long‐Distance Pathways Maintain Homeostasis -- Control Systems Vary in Their Speed and Specificity -- Complex Reflex Control Pathways Have Several Integrating Centers -- CHAPTER SUMMARY -- REVIEW QUESTIONS -- UNIT 2 Homeostasis and Control -- Chapter 7: Introduction to the Endocrine System -- Hormones -- RUNNING PROBLEM Graves' Disease -- Hormones Have Been Known Since Ancient Times -- CLINICAL FOCUS Diabetes: The Discovery of Insulin -- What Makes a Chemical a Hormone? -- Hormones Act by Binding to Receptors -- Hormone Action Must Be Terminated -- The Classification of Hormones -- Most Hormones Are Peptides or Proteins -- Steroid Hormones Are Derived from Cholesterol -- Some Hormones Are Derived from Single Amino Acids -- Control of Hormone Release -- The Endocrine Cell Is the Sensor in Simple Endocrine Reflexes.
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|a Many Endocrine Reflexes Involve the Nervous System.
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|a For courses in Human Physiology. Move beyond memorization: Prepare students for tomorrow's challenges Human Physiology: An Integrated Approach is the #1 best-selling 1-semester human physiology text world-wide. The 8th Edition engages students in developing a deeper understanding of human physiology by guiding them to think critically and equipping them to solve real-world problems. Updates, such as new Try It activities and detailed teaching suggestions in the new Ready-to-Go Teaching Modules, help students learn and apply mapping skills, graphing skills, and data interpretation skills. The text reflects Dr. Silverthorn's active learning style of instruction and builds upon the thorough integration of "big picture" themes with up-to-date cellular and molecular physiology topics that have always been the foundation of her approach. Pearson Mastering A&P is not included. Students, if Mastering A&P is a recommended/mandatory component of the course, please ask your instructor for the correct ISBN. Pearson Mastering A&P should only be purchased when required by an instructor. Instructors, contact your Pearson representative for more information. Reach every student by pairing this text with Pearson Mastering A&P Mastering™ is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools and a flexible platform, Mastering personalizes the learning experience and improves results for each student.
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|a AS201 - Bachelor of Science (Hons.) Biology
|z Syllabus Programme
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| 588 |
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|a Description based on publisher supplied metadata and other sources.
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| 590 |
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|a Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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| 650 |
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|a Human physiology.
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| 655 |
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|a Electronic books.
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|a Faculty of Applied Sciences
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|a Zuliahani Ahmad
|e Requestor
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|i Print version:
|a Silverthorn, Dee Unglaub
|t Human Physiology: An Integrated Approach, Global Edition
|d Harlow, United Kingdom : Pearson Education Limited,c2018
|z 9781292259543
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| 797 |
2 |
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|a ProQuest (Firm)
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| 856 |
4 |
0 |
|u https://ezaccess.library.uitm.edu.my/login?url=https://ebookcentral.proquest.com/lib/uitm-ebooks/detail.action?docID=5573692
|z View fulltext via EzAccess
|