|
|
|
|
| LEADER |
11434nam a22005413i 4500 |
| 001 |
EBC5325063 |
| 003 |
MiAaPQ |
| 005 |
20210318061024.0 |
| 006 |
m o d | |
| 007 |
cr cnu|||||||| |
| 008 |
210318s2018 xx o ||||0 eng d |
| 020 |
|
|
|a 9780702072970
|q (electronic bk.)
|
| 020 |
|
|
|z 9780702072987
|
| 035 |
|
|
|a (MiAaPQ)EBC5325063
|
| 035 |
|
|
|a (Au-PeEL)EBL5325063
|
| 035 |
|
|
|a (CaPaEBR)ebr11532057
|
| 035 |
|
|
|a (OCoLC)1029485522
|
| 040 |
|
|
|a MiAaPQ
|b eng
|e rda
|e pn
|c MiAaPQ
|d MiAaPQ
|
| 050 |
|
4 |
|a QP514.2
|b .M877 2019
|
| 082 |
0 |
|
|a 574.192
|
| 100 |
1 |
|
|a Murphy, Michael.
|
| 245 |
1 |
0 |
|a Clinical Biochemistry E-Book :
|b An Illustrated Colour Text.
|
| 250 |
|
|
|a 6th ed.
|
| 264 |
|
1 |
|a Philadelphia :
|b Elsevier,
|c 2018.
|
| 264 |
|
4 |
|c ©2019.
|
| 300 |
|
|
|a 1 online resource (190 pages)
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 490 |
1 |
|
|a Illustrated Colour Text Ser.
|
| 505 |
0 |
|
|a Front Cover -- Inside Front Cover -- Clinical Biochemistry -- Copyright Page -- Preface -- Acknowledgements -- Table Of Contents -- 1 Introducing clinical biochemistry -- 1 The clinical biochemistry laboratory -- The use of biochemical tests -- Core biochemistry -- Specialised tests -- Urgent samples -- Automation and computerisation -- Test repertoire -- Laboratory personnel -- 2 The use of the laboratory -- Specimen collection -- Blood specimens -- Urine specimens -- High-risk specimens -- Sampling errors -- Analysing the specimen -- Timing -- Unnecessary testing -- 3 Interpretation of results -- How biochemical results are expressed -- Units -- Reference intervals -- Biological factors affecting 'normality' -- Health versus disease -- 4 Interpretation of results -- Diagnostic test outcomes -- The impact of prevalence on test utility -- Final thoughts -- 5 Interpretation of results -- Sources of variation -- Pre-analytical variation -- Analytical variation -- Biological variation -- Other biological variation -- 6 Analytical aspects -- Precision and accuracy -- Analytical sensitivity and specificity -- Quality assurance -- 2 Core biochemistry -- 7 Fluid and electrolytes -- Body fluid compartments -- Evaluation of hydration -- Osmolality -- Oncotic pressure -- 8 Water and sodium balance -- Water -- AVP and the regulation of osmolality -- Sodium -- Aldosterone -- Atrial natriuretic peptide -- Regulation of volume -- 9 Hyponatraemia -- Mechanisms of hyponatraemia -- Water retention -- Sodium loss -- Sodium depletion - a word of caution -- Pseudohyponatraemia -- 10 Hyponatraemia -- Clinical assessment -- Severity -- Mechanism -- History -- Clinical examination -- Biochemistry -- Oedema -- Treatment -- 11 Hypernatraemia -- Water loss -- Sodium gain -- Clinical features -- Treatment -- Other osmolality disorders -- 12 Hyperkalaemia.
|
| 505 |
8 |
|
|a Serum potassium and potassium balance -- Hyperkalaemia -- Decreased excretion -- Redistribution out of cells -- Increased intake -- Treatment -- Pseudohyperkalaemia -- 13 Hypokalaemia -- Diagnosis -- Redistribution into cells -- Increased losses -- Gastrointestinal -- Urinary -- Investigation -- Treatment -- 14 Intravenous fluid therapy -- Does this patient need IV fluids? -- Which IV fluids should be given? -- How much fluid should be given? -- Existing losses -- Anticipated losses -- How quickly should the fluids be given? -- Perioperative patient -- How should the fluid therapy be monitored? -- 15 Investigation of renal function (1) -- Functions of the kidney -- Glomerular function -- Serum creatinine -- Estimated GFR (eGFR) -- Other ways of measuring GFR -- Creatinine clearance -- Proteinuria -- Endocrine aspects -- 16 Investigation of renal function (2) -- Renal tubular function -- Tubular dysfunction -- Investigation of tubular function -- Osmolality measurements in plasma and urine -- The water deprivation test -- Renal tubular acidosis -- Specific proteinuria -- Glycosuria -- Aminoaciduria -- Specific tubular defects -- The Fanconi syndrome -- Renal stones -- 17 Urinalysis -- Procedure -- Glucose -- Bilirubin -- Urobilinogen -- Ketones -- Specific gravity -- pH (hydrogen ion concentration) -- Protein -- Blood -- Nitrite -- Leucocytes -- 18 Proteinuria -- Mechanisms of proteinuria -- Glomerular proteinuria -- Tubular proteinuria -- Overflow proteinuria -- Tamm-Horsfall proteinuria -- Ways of measuring proteinuria -- Dipstick urinalysis -- Protein/creatinine ratio -- Urine protein excretion -- Albumin/creatinine ratio and 'microalbuminuria' -- 19 Acute kidney injury -- Aetiology -- Detection of AKI -- Identifying the cause of AKI -- Acute tubular necrosis -- Management -- Recovery -- 20 Chronic kidney disease -- Consequences of CKD.
|
| 505 |
8 |
|
|a Sodium and water metabolism -- Potassium metabolism -- Acid-base balance -- Calcium and phosphate metabolism -- Erythropoietin synthesis -- Clinical features -- Detection -- Classification -- Management -- Dialysis -- Renal transplant -- 21 Acid-base -- Hydrogen ion concentration [H+] -- H+ production -- Buffering -- Renal handling of H+ and HCO3− -- Assessing status -- Acid-base disorders -- Terminology -- Compensation -- 22 Metabolic acid-base disorders -- Metabolic acidosis -- The anion gap -- Causes of metabolic acidosis -- Clinical effects of acidosis -- Metabolic alkalosis -- Clinical effects of alkalosis -- 23 Respiratory and mixed acid-base disorders -- Respiratory acidosis -- Respiratory alkalosis -- Mixed acid-base disorders -- 24 Acid-base disorders -- Specimens for blood gas analysis -- Interpreting results -- Clinical cases -- Management of acid-base disorders -- 25 Proteins and enzymes -- Enzymes -- Plasma enzymes in disease -- Plasma proteins -- Total protein -- Albumin -- Specific proteins -- Isoenzyme determination -- Cholinesterase -- 26 Immunoglobulins -- Structure -- Electrophoresis of serum proteins -- Increased immunoglobulins -- Paraproteins -- Deficiencies or absence of immunoglobulins -- 27 Myocardial infarction -- Pathology -- Cardiac biomarkers -- Diagnosis -- Definitions -- Acute coronary syndrome -- Myocardial infarction -- 28 Liver function tests -- Introduction -- Liver function tests -- The aminotransferases (ALT and AST) -- Alkaline phosphatase (ALK) -- Bilirubin -- Gamma-glutamyl transpeptidase (GGT) -- Plasma proteins -- Prothrombin time -- 29 Jaundice -- Biochemical tests -- Differential diagnosis -- Haemolysis -- Extrahepatic biliary obstruction -- Hepatocellular damage -- 30 Liver disease -- Acute liver disease -- Investigation -- Poisoning -- Liver infection -- Outcome -- Hepatic failure -- Chronic liver disease.
|
| 505 |
8 |
|
|a Aetiology -- Clinical features -- Unusual causes of cirrhosis -- Other liver problems -- 31 Glucose metabolism and diabetes mellitus -- Insulin -- Diabetes mellitus -- Type 1 diabetes mellitus -- Type 2 diabetes mellitus -- Late complications of diabetes mellitus -- 32 Diagnosis and monitoring of diabetes mellitus -- Diagnosis of diabetes mellitus -- Plasma glucose -- Glycated haemoglobin (HbA1c) -- Monitoring of diabetes -- Self-monitoring -- Ketones in urine or blood -- 33 Diabetic ketoacidosis -- How diabetic ketoacidosis develops -- Treatment -- Laboratory investigations -- Hyperosmolar hyperglycaemic state (HHS) -- Diagnosis -- Treatment -- 34 Hypoglycaemia -- Clinical effects -- Assessment -- Specific causes of hypoglycaemia -- Fasting hypoglycaemia -- Reactive hypoglycaemia -- Diabetic patients -- Neonatal hypoglycaemia -- 35 Calcium regulation and hypocalcaemia -- Calcium homeostasis -- Serum calcium -- Hypocalcaemia -- Clinical features -- Treatment -- 36 Hypercalcaemia -- Clinical features -- Diagnosis -- Treatment -- Familial benign hypercalcaemia -- 37 Phosphate and magnesium -- Phosphate -- Inorganic phosphate -- Hyperphosphataemia -- Hypophosphataemia -- Magnesium -- Magnesium homeostasis -- Serum magnesium -- Magnesium deficiency -- Laboratory diagnosis -- Management -- 38 Metabolic bone disease -- Bone metabolism -- Common bone disorders -- Osteoporosis -- Osteomalacia and rickets -- Paget's disease of bone -- Other bone diseases -- Biochemistry testing in calcium disorders or bone disease -- 39 Osteoporosis and fragility fractures -- Risk factors -- Diagnosis -- Principles of treatment -- 3 Endocrinology -- 40 Endocrine control -- Biochemical regulators -- Hormone structure -- Assessment of endocrine control -- Types of endocrine control -- Negative feedback -- Positive feedback -- Pitfalls in interpretation -- Dynamic function tests.
|
| 505 |
8 |
|
|a 41 Dynamic function tests -- Insulin stress test -- TRH test -- GnRH test -- Oral glucose tolerance test with GH measurement -- Synacthen tests -- Short Synacthen test -- Long Synacthen test -- Dexamethasone suppression tests -- Low-dose DST -- High-dose DST -- Dynamic function tests - protocol variation -- 42 Pituitary function -- The pituitary gland -- Anterior pituitary hormones -- Hyperprolactinaemia -- Posterior pituitary hormones -- Pituitary tumours -- Diagnosis -- Treatment -- Hypopituitarism -- 43 Growth disorders and acromegaly -- Normal growth -- Growth hormone insufficiency -- Tests of growth hormone insufficiency -- Treatment -- Excessive growth -- Acromegaly -- Diagnosis -- Treatment -- 44 Thyroid pathophysiology -- Goitre -- Thyroid hormone action -- Binding in plasma -- Regulation of thyroid hormone secretion -- Thyroid function tests -- Drugs and the thyroid -- 45 Hypothyroidism -- Clinical features -- Causes -- Diagnosis -- Treatment -- Screening for neonatal hypothyroidism -- Non-thyroidal illness -- 46 Hyperthyroidism -- Clinical features -- Causes -- Diagnosis -- Treatment -- Thyroid eye disease -- 47 Adrenocortical pathophysiology -- Cortisol -- Adrenal androgens -- Assessing the function of the HPA axis -- Aldosterone -- Congenital adrenal hyperplasia -- Relationship of adrenal cortex and medulla -- 48 Hypofunction of the adrenal cortex -- Adrenal insufficiency -- Clinical features -- Pathogenesis -- Diagnosis -- Random cortisol -- Synacthen tests -- Causes of adrenal insufficiency -- Relative adrenal insufficiency -- 49 Hyperfunction of the adrenal cortex -- Cortisol excess -- Confirming the diagnosis -- Overnight dexamethasone suppression test -- Determining the cause -- Plasma ACTH -- DST -- Androgen excess -- Aldosterone excess -- 50 Gonadal function -- Sex steroid hormones -- Hypothalamic-pituitary-gonadal axis.
|
| 505 |
8 |
|
|a Male gonadal function.
|
| 526 |
0 |
|
|a HS111 - Diploma in Medical Laboratory Technology
|z References
|
| 588 |
|
|
|a Description based on publisher supplied metadata and other sources.
|
| 590 |
|
|
|a Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2021. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
|
| 650 |
|
0 |
|a Biochemistry.
|
| 655 |
|
4 |
|a Electronic books.
|
| 700 |
1 |
|
|a Srivastava, Rajeev.
|
| 700 |
1 |
|
|a Deans, Kevin.
|
| 776 |
0 |
8 |
|i Print version:
|a Murphy, Michael
|t Clinical Biochemistry E-Book
|d Philadelphia : Elsevier,c2018
|z 9780702072987
|
| 797 |
2 |
|
|a ProQuest (Firm)
|
| 830 |
|
0 |
|a Illustrated Colour Text Ser.
|
| 856 |
4 |
0 |
|u https://ezaccess.library.uitm.edu.my/login?url=https://ebookcentral.proquest.com/lib/uitm-ebooks/detail.action?docID=5325063
|z View fulltext via EzAccess
|
| 966 |
0 |
|
|a 2021
|b ProQuest Ebook Central
|c UiTM Library
|d Dr. Wan Ismahanisa Ismail
|e Faculty of Health Sciences
|f ProQuest
|