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Becker's World of the Cell, Global Edition.

For courses in cell biology.Explore the world of the cellWidely praised for its strong biochemistry coverage and clear, easy-to-follow explanations and figures, Becker's World of the Cell provides a beautifully-illustrated, up-to-date introduction to cell biology concepts, processes, and applic...

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Bibliographic Details
Main Author: Hardin, Jeff.
Other Authors: Bertoni, Gregory Paul., Kleinsmith, Lewis J.
Format: eBook
Language:English
Published: Harlow, United Kingdom : Pearson Education, Limited, 2017.
Edition:9th ed.
Subjects:
Electronic books.
Online Access:View fulltext via EzAccess
Table of Contents:
  • Front Cover
  • About the Authors
  • Brief Contents
  • Detailed Contents
  • Preface
  • Acknowledgments
  • Chapter 1: A Preview of Cell Biology
  • 1.1: The Cell Theory: A Brief History
  • Advances in Microscopy Allowed Detailed Studies of Cells
  • The Cell Theory Applies to All Organisms
  • 1.2: The Emergence of Modern Cell Biology
  • The Cytological Strand Deals with Cellular Structure
  • The Biochemical Strand Studies the Chemistry of Biological Structure and Function
  • The Genetic Strand Focuses on Information Flow
  • 1.3: How Do We Know What We Know?
  • Biological "Facts" May Turn Out to Be Incorrect
  • Experiments Test Specific Hypotheses
  • Model Organisms Play a Key Role in Modern Cell Biology Research
  • Well-Designed Experiments Alter Only One Variable at a Time
  • Summary of Key Points
  • Problem Set
  • Key Technique: Using Immunofluorescence to Identify Specific Cell Components
  • Human Connections: The Immortal Cells of Henrietta Lacks
  • Chapter 2: The Chemistry of the Cell
  • 2.1: The Importance of Carbon
  • Carbon-Containing Molecules Are Stable
  • Carbon-Containing Molecules Are Diverse
  • Carbon-Containing Molecules Can Form Stereoisomers
  • 2.2: The Importance of Water
  • Water Molecules Are Polar
  • Water Molecules Are Cohesive
  • Water Has a High Temperature-Stabilizing Capacity
  • Water Is an Excellent Solvent
  • 2.3: The Importance of Selectively Permeable Membranes
  • A Membrane Is a Lipid Bilayer with Proteins Embedded in It
  • Lipid Bilayers Are Selectively Permeable
  • 2.4: The Importance of Synthesis by Polymerization
  • Macromolecules Are Critical for Cellular Form and Function
  • Cells Contain Three Different Kinds of Macromolecular Polymers
  • Macromolecules Are Synthesized by Stepwise Polymerization of Monomers
  • 2.5: The Importance of Self-Assembly.
  • Noncovalent Bonds and Interactions Are Important in the Folding of Macromolecules
  • Many Proteins Spontaneously Fold into Their Biologically Functional State
  • Molecular Chaperones Assist the Assembly of Some Proteins
  • Self-Assembly Also Occurs in Other Cellular Structures
  • The Tobacco Mosaic Virus Is a Case Study in Self-Assembly
  • Self-Assembly Has Limits
  • Hierarchical Assembly Provides Advantages for the Cell
  • Summary of Key Points
  • Problem Set
  • Key Technique: Determining the Chemical Fingerprint of a Cell Using Mass Spectrometry
  • Human Connections: Taking a Deeper Look: Magnetic Resonance Imaging (MRI)
  • Chapter 3: The Macromolecules of the Cell
  • 3.1: Proteins
  • The Monomers Are Amino Acids
  • The Polymers Are Polypeptides and Proteins
  • Several Kinds of Bonds and Interactions Are Important in Protein Folding and Stability
  • Protein Structure Depends on Amino Acid Sequence and Interactions
  • 3.2: Nucleic Acids
  • The Monomers Are Nucleotides
  • The Polymers Are DNA and RNA
  • A DNA Molecule Is a Double-Stranded Helix
  • 3.3: Polysaccharides
  • The Monomers Are Monosaccharides
  • The Polymers Are Storage and Structural Polysaccharides
  • Polysaccharide Structure Depends on the Kinds of Glycosidic Bonds Involved
  • 3.4: Lipids
  • Fatty Acids Are the Building Blocks of Several Classes of Lipids
  • Triacylglycerols Are Storage Lipids
  • Phospholipids Are Important in Membrane Structure
  • Glycolipids Are Specialized Membrane Components
  • Steroids Are Lipids with a Variety of Functions
  • Terpenes Are Formed from Isoprene
  • Summary of Key Points
  • Problem Set
  • Human Connections: Aggregated Proteins and Alzheimer's
  • Key Technique: Using X-Ray Crystallography to Determine Protein Structure
  • Chapter 4: Cells and Organelles
  • 4.1: Where Did the First Cells Come From?.
  • Simple Organic Molecules May Have Formed Abiotically in the Young Earth
  • RNA May Have Been the First Informational Molecule
  • Liposomes May Have Defined the First Primitive Protocells
  • 4.2: Properties and Strategies of Cells
  • All Organisms Are Bacteria, Archaea, or Eukaryotes
  • There Are Several Limitations on Cell Size
  • Bacteria, Archaea, and Eukaryotes Differ from Each Other in Many Ways
  • 4.3: The Eukaryotic Cell in Overview: Structure and Function
  • The Plasma Membrane Defines Cell Boundaries and Retains Contents
  • The Nucleus Is the Information Center of the Eukaryotic Cell
  • Mitochondria and Chloroplasts Provide Energy for the Cell
  • The Endosymbiont Theory Proposes That Mitochondria and Chloroplasts Were Derived From Bacteria
  • The Endomembrane System Synthesizes Proteins for a Variety of Cellular Destinations
  • Other Organelles Also Have Specific Functions
  • Ribosomes Synthesize Proteins in the Cytoplasm
  • The Cytoskeleton Provides Structure to the Cytoplasm
  • The Extracellular Matrix and Cell Walls Are Outside the Plasma Membrane
  • 4.4: Viruses, Viroids, and Prions: Agents That Invade Cells
  • A Virus Consists of a DNA or RNA Core Surrounded by a Protein Coat
  • Viroids Are Small, Circular RNA Molecules That Can Cause Plant Diseases
  • Prions Are Infectious Protein Molecules
  • Summary of Key Points
  • Problem Set
  • Human Connections: When Cellular "Breakdown" Breaks Down
  • Key Technique: Using Centrifugation to Isolate Organelles
  • Chapter 5: Bioenergetics: The Flow of Energy in the Cell
  • 5.1: The Importance of Energy
  • Cells Need Energy to Perform Six Different Kinds of Work
  • Organisms Obtain Energy Either from Sunlight or from the Oxidation of Chemical Compounds
  • Energy Flows Through the Biosphere Continuously
  • The Flow of Energy Through the Biosphere Is Accompanied by a Flow of Matter.
  • 5.2: Bioenergetics
  • Understanding Energy Flow Requires Knowledge of Systems, Heat, and Work
  • The First Law of Thermodynamics States That Energy Is Conserved
  • The Second Law of Thermodynamics States That Reactions Have Directionality
  • Entropy and Free Energy Are Two Means of Assessing Thermodynamic Spontaneity
  • 5.3: Understanding ∆G and Keq
  • The Equilibrium Constant Keq Is a Measure of Directionality
  • ∆G Can Be Calculated Readily
  • The Standard Free Energy Change Is ∆G Measured Under Standard Conditions
  • Summing Up: The Meaning of ∆G´ and ∆G˚´
  • Free Energy Change: Sample Calculations
  • Jumping Beans Provide a Useful Analogy for Bioenergetics
  • Life Requires Steady-State Reactions That Move Toward Equilibrium Without Ever Getting There
  • Summary of Key Points
  • Problem Set
  • Human Connections: The "Potential" of Food to Provide Energy
  • Key Technique: Measuring How Molecules Bind to One Another Using Isothermal Titration Calorimetry
  • Chapter 6: Enzymes: The Catalysts of Life
  • 6.1: Activation Energy and the Metastable State
  • Before a Chemical Reaction Can Occur, the Activation Energy Barrier Must Be Overcome
  • The Metastable State Is a Result of the Activation Barrier
  • Catalysts Overcome the Activation Energy Barrier
  • 6.2: Enzymes as Biological Catalysts
  • Most Enzymes Are Proteins
  • Substrate Binding, Activation, and Catalysis Occur at the Active Site
  • Ribozymes Are Catalytic RNA Molecules
  • 6.3: Enzyme Kinetics
  • Monkeys and Peanuts Provide a Useful Analogy for Understanding Enzyme Kinetics
  • Most Enzymes Display Michaelis-Menten Kinetics
  • What Is the Meaning of Vmax and Km?
  • Why Are Km and Vmax Important to Cell Biologists?
  • The Double-Reciprocal Plot Is a Useful Means of Visualizing Kinetic Data
  • Enzyme Inhibitors Act Either Irreversibly or Reversibly
  • 6.4: Enzyme Regulation.
  • Allosteric Enzymes Are Regulated by Molecules Other than Reactants and Products
  • Allosteric Enzymes Exhibit Cooperative Interactions Between Subunits
  • Enzymes Can Also Be Regulated by the Addition or Removal of Chemical Groups
  • Summary of Key Points
  • Problem Set
  • Human Connections: ACE Inhibitors: Enzyme Activity as the Difference Between Life and Death
  • Key Technique: Determining Km and Vmax Using Enzyme Assays
  • Chapter 7: Membranes: Their Structure, Function, and Chemistry
  • 7.1: The Functions of Membranes
  • Membranes Define Boundaries and Serve as Permeability Barriers
  • Membranes Are Sites of Specific Proteins and Therefore of Specific Functions
  • Membrane Proteins Regulate the Transport of Solutes
  • Membrane Proteins Detect and Transmit Electrical and Chemical Signals
  • Membrane Proteins Mediate Cell Adhesion and Cell-to-Cell Communication
  • 7.2: Models of Membrane Structure: An Experimental Perspective
  • Overton and Langmuir: Lipids Are Important Components of Membranes
  • Gorter and Grendel: The Basis of Membrane Structure Is a Lipid Bilayer
  • Davson and Danielli: Membranes Also Contain Proteins
  • Robertson: All Membranes Share a Common Underlying Structure
  • Further Research Revealed Major Shortcomings of the Davson-Danielli Model
  • Singer and Nicolson: A Membrane Consists of a Mosaic of Proteins in a Fluid Lipid Bilayer
  • Unwin and Henderson: Most Membrane Proteins Contain Transmembrane Segments
  • Recent Findings Suggest Membranes Are Organized into Microdomains
  • 7.3: Membrane Lipids: The "Fluid" Part of the Model
  • Membranes Contain Several Major Classes of Lipids
  • Fatty Acids Are Essential to Membrane Structure and Function
  • Thin-Layer Chromatography Is an Important Technique for Lipid Analysis
  • Membrane Asymmetry: Most Lipids Are Distributed Unequally Between the Two Monolayers.
  • The Lipid Bilayer Is Fluid.

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