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110713s2010 xxu| s |||| 0|eng d |
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|a 9781441978233
|9 978-1-4419-7823-3
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|a 10.1007/978-1-4419-7823-3
|2 doi
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|a Gro<U+00df>hans, Helge.
|e editor.
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|a Regulation of microRNAs
|c edited by Helge Gro<U+00df>hans.
|h [electronic resource] /
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|a New York, NY :
|b Springer US,
|c 2010.
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| 300 |
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|a XVI, 160p. 35 illus., 6 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a text file
|b PDF
|2 rda
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|a Advances in Experimental Medicine and Biology,
|v 700
|x 0065-2598 ;
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|a microRNA BIOGENESIS AND FUNCTION - AN OVERVIEW -- REGULATION OF pri<U+0011>miRNA PROCESING THROUGH Smads -- STIMULATION OF pri<U+0011>miR<U+0011>18a PROCESING BY hnRNP A1 -- KSRP PROMOTES THE MATURATION OF A GROUP OF miRNA PRECURSORS -- Hormonal Repression of mirna Biosynthesis Through a Nuclear Steroid Hormone Receptor -- Autoregulatory mechanisms controlling the Microprocessor -- Regulation of pre<U+0011>miRNA processing -- THE EFECT OF RNA EDITING AND ADARs ON miRNA BIOGENESIS AND FUNCTION -- miRNAs need a Trim Regulation of miRNA Activity by Trim-NHL Proteins -- Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA -- Turnover of Mature miRNAs and siRNAs in Plants and Algae -- MicroRNases and the regulated degradation of mature animal miRNAs.
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|a Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.
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|a Medicine.
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| 650 |
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|a Human genetics.
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| 650 |
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|a Biomedicine.
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| 650 |
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|a Biomedicine general.
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| 650 |
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|a Human Genetics.
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| 710 |
2 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9781441978226
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| 830 |
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|a Advances in Experimental Medicine and Biology,
|v 700
|x 0065-2598 ;
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| 856 |
4 |
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|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-7823-3
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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