The Rho GTPases in Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Golen, Kenneth. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York, 2010.
• Subjects: Medicine.; Oncology.; Toxicology.; Cytology.; Biomedicine.; Cancer Research.; Cell Biology.; Pharmacology/Toxicology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-1111-7

The Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasi...

Table of Contents:

• Overview of Rho GTPase History 1
• Rho GTPases and Cancer 43
• RhoGDIs in Cancer 67
• Signaling through Galpha12/13 and RGS-RhoGEFs 93
• Vav Proteins In Cancer 126
• Rho GTPase-Activating Proteins in Cancer 156
• RhoBTB Proteins in Cancer 182
• RhoC GTPase in Cancer Progression and Metastasis 197
• RhoB GTPase and Farnesyl Transferase Inhibitors (FTIs) in Cancer 219
• Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview 257
• The Rho-Regulated ROCK Kinases in Cancer 273.