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100301s2010 xxu| s |||| 0|eng d |
| 020 |
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|a 9781441911117
|9 978-1-4419-1111-7
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| 024 |
7 |
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|a 10.1007/978-1-4419-1111-7
|2 doi
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| 050 |
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|a RC261-271
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| 072 |
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|a MJCL
|2 bicssc
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| 072 |
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|a MED062000
|2 bisacsh
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| 082 |
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|a 614.5999
|2 23
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| 100 |
1 |
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|a Golen, Kenneth.
|e editor.
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| 245 |
1 |
4 |
|a The Rho GTPases in Cancer
|c edited by Kenneth Golen.
|h [electronic resource] /
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| 264 |
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1 |
|a New York, NY :
|b Springer New York,
|c 2010.
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| 300 |
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|a XXII, 206p. 25 illus., 13 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 347 |
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|a text file
|b PDF
|2 rda
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|a Overview of Rho GTPase History 1 -- Rho GTPases and Cancer 43 -- RhoGDIs in Cancer 67 -- Signaling through Galpha12/13 and RGS-RhoGEFs 93 -- Vav Proteins In Cancer 126 -- Rho GTPase-Activating Proteins in Cancer 156 -- RhoBTB Proteins in Cancer 182 -- RhoC GTPase in Cancer Progression and Metastasis 197 -- RhoB GTPase and Farnesyl Transferase Inhibitors (FTIs) in Cancer 219 -- Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview 257 -- The Rho-Regulated ROCK Kinases in Cancer 273.
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| 520 |
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|a The Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.
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| 650 |
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|a Medicine.
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| 650 |
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|a Oncology.
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| 650 |
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|a Toxicology.
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| 650 |
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|a Cytology.
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| 650 |
1 |
4 |
|a Biomedicine.
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| 650 |
2 |
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|a Cancer Research.
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| 650 |
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4 |
|a Cell Biology.
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| 650 |
2 |
4 |
|a Pharmacology/Toxicology.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
0 |
8 |
|i Printed edition:
|z 9781441911100
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| 856 |
4 |
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|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-1111-7
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
|