Telomeres and Telomerase in Cancer
Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also...
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| Format: | Electronic |
| Language: | English |
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Totowa, NJ :
Humana Press,
2009.
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| Series: | Cancer Drug Discovery and Development
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| Online Access: | https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-60327-879-9 |
Table of Contents:
- Part I. Basic background. 1 Telomeres and Telomerase in Human. 2 Telomere Binding Proteins in Human. 3 Regulation of Telomerase through Transcriptional and Post-Translational Mechanisms. 4 Telomere Dysfunction and the DNA Damage Response. 5 Alternative Lengthening of Telomeres (ALT) in Human Cells. 6 Mouse model: Telomeres and Telomerase in Stem Cell and Cancer
- Part II Telomeres and telomerase in human cancers. 7 Role of Telomeres and Telomerase in Cancer. 8 Diagnostic Value 1: Solid Tumors. 9 Diagnostic Value 2: Hematopoietic Malignancies. 10 Therapeutic Targets and Drugs 1: Telomerase and Telomerase Inhibitors. 11 Therapeutic Targets and Drugs 2: G-quadruplex and G-quadruplex Inhibitors. 12 Therapeutic Targets and Drugs 3: Tankyrase 1, Telomere Binding Proteins, and Inhibitors. 13 Therapeutic Targets and Drugs 4: Telomerase-specific Gene and Vector-based Therapies for Human Cancer
- Part III Experimental protocols. 14 Protocol 1: Telomerase Activity and Telomerase Expression . 15 Protocol 2: Importance and Methods of Telomere G-tail Length Quantification . 16 Protocol 3: Detection of Alternative Lengthening of Telomeres (ALT). Index.