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100301s2009 xxu| s |||| 0|eng d |
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|a 9781603278799
|9 978-1-60327-879-9
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|a 10.1007/978-1-60327-879-9
|2 doi
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|a RC261-271
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|a MJCL
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|a MED062000
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|a 614.5999
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|a Hiyama, Keiko.
|e editor.
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|a Telomeres and Telomerase in Cancer
|c edited by Keiko Hiyama.
|h [electronic resource] /
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|a Totowa, NJ :
|b Humana Press,
|c 2009.
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|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
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|2 rdamedia
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|a online resource
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|a text file
|b PDF
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|a Cancer Drug Discovery and Development
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|a Part I. Basic background. 1 Telomeres and Telomerase in Human. 2 Telomere Binding Proteins in Human. 3 Regulation of Telomerase through Transcriptional and Post-Translational Mechanisms. 4 Telomere Dysfunction and the DNA Damage Response. 5 Alternative Lengthening of Telomeres (ALT) in Human Cells. 6 Mouse model: Telomeres and Telomerase in Stem Cell and Cancer -- Part II Telomeres and telomerase in human cancers. 7 Role of Telomeres and Telomerase in Cancer. 8 Diagnostic Value 1: Solid Tumors. 9 Diagnostic Value 2: Hematopoietic Malignancies. 10 Therapeutic Targets and Drugs 1: Telomerase and Telomerase Inhibitors. 11 Therapeutic Targets and Drugs 2: G-quadruplex and G-quadruplex Inhibitors. 12 Therapeutic Targets and Drugs 3: Tankyrase 1, Telomere Binding Proteins, and Inhibitors. 13 Therapeutic Targets and Drugs 4: Telomerase-specific Gene and Vector-based Therapies for Human Cancer -- Part III Experimental protocols. 14 Protocol 1: Telomerase Activity and Telomerase Expression . 15 Protocol 2: Importance and Methods of Telomere G-tail Length Quantification . 16 Protocol 3: Detection of Alternative Lengthening of Telomeres (ALT). Index.
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|a Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase positive cells, and consequence of telomerase inhibition are different among species. "Telomeres and Telomerase in Cancers", edited by Keiko Hiyama, focuses on "Human" telomeres and telomerase, from basic biology and hypothesis in human normal cells and cancer cells to clinical application as diagnostic tools and therapeutic targets in anti-cancer strategy. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer.
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|a Medicine.
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|a Oncology.
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|a Toxicology.
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|a Biomedicine.
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|a Cancer Research.
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|a Oncology.
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|a Pharmacology/Toxicology.
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| 710 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9781603273060
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| 830 |
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|a Cancer Drug Discovery and Development
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|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-60327-879-9
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|a ZDB-2-SBL
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|a Biomedical and Life Sciences (Springer-11642)
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