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100301s2009 xxu| s |||| 0|eng d |
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|a 9780387691794
|9 978-0-387-69179-4
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|a 10.1007/978-0-387-69179-4
|2 doi
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|a RC261-271
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|a MJCL
|2 bicssc
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|a MED062000
|2 bisacsh
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|a 614.5999
|2 23
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|a Mohler, James.
|e editor.
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|a Androgen Action in Prostate Cancer
|c edited by James Mohler, Donald Tindall.
|h [electronic resource] /
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| 264 |
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1 |
|a New York, NY :
|b Springer US,
|c 2009.
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| 300 |
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|a VIII, 826 p.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a text file
|b PDF
|2 rda
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|a From the contents Introduction: History, Nomenclature, Topic and Author Selection, Goals and Objectives -- 1. The Role of Androgens in Development of the Normal Prostate and Progression of Prostate Cancer -- 2. Androgen Action and Modulation of Prostate and Prostate Cancer Growth: An Overview of Research in The Authors Laboratory -- 3. Clinical progression to castration-recurrent prostate cancer -- 4. Androgen Metabolism -- 5. Increased expression of genes converting adrenal androgens to testosterone in castration-recurrent prostate cancer -- 6. Androgen metabolic genes in prostate cancer predisposition and progression -- 7. Effect of Steroid 5a -Reductase Inhibitors on Markers of Tumor Regression and Proliferation in Prostate Cancer. 8. 5a-Reductase Isozymes in Castration-Recurrent Prostate Cancer -- 9. Androgen Receptor Structure/Function Relationships.
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|a This book serves as a tribute to the work of the many investigators who have attempted to understand the role of the androgen receptor (AR) in the development and progression of prostate cancer. The relationship between prostate cancer and androgen status was initially appreciated in the late 1800 s, and then awareness reawakened in the 1940 s by the studies of Charles Huggins and colleagues, for which the Nobel prize was awarded in 1966. The purpose of this book is to provide an up to date review of the molecular and cellular aspects of androgen action in prostate cancer. It includes an overview of the role of androgens in the development of the normal prostate and progression of prostate cancer. Our understanding of androgen metabolism and efforts to target androgen metabolism in the prevention and treatment of prostate cancer is presented. Androgen receptor structure/function relationships and the role of co-regulators are defined. Ligand-independent activation of the androgen receptor and the role of the androgen receptor during progression to the castration recurrent phenotype are discussed. Androgen-regulated genes are elucidated and their roles during prostate cancer progression are defined. Finally, the androgen receptor is presented as a viable target for novel therapies. Together, these reviews should give the reader a comprehensive conceptual framework of androgen action in prostate cancer.
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| 650 |
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|a Medicine.
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| 650 |
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|a Oncology.
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| 650 |
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|a Human genetics.
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| 650 |
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|a Immunology.
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| 650 |
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|a Microbiology.
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| 650 |
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|a Toxicology.
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| 650 |
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|a Medical virology.
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| 650 |
1 |
4 |
|a Biomedicine.
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| 650 |
2 |
4 |
|a Cancer Research.
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| 650 |
2 |
4 |
|a Human Genetics.
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| 650 |
2 |
4 |
|a Medical Microbiology.
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| 650 |
2 |
4 |
|a Pharmacology/Toxicology.
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| 650 |
2 |
4 |
|a Immunology.
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| 650 |
2 |
4 |
|a Virology.
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| 700 |
1 |
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|a Tindall, Donald.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9780387691770
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| 856 |
4 |
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|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-0-387-69179-4
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
|