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Tissue engineering of temporomandibular joint cartilage

The temporomandibular joint (TMJ) is a site of intense morbidity for millions of people, especially young, pre-menopausal women. Central to TMJ afflictions are the cartilaginous tissues of the TMJ, especially those of the disc and condylar cartilage, which play crucial roles in normal function of th...

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Bibliographic Details
Other Authors: Athanasiou, K. A.
Format: Electronic
Language:English
Published: San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool Publishers, c2009.
Series:Synthesis lectures on tissue engineering (Online), # 2.
Subjects:
Temporomandibular joint > Diseases > Treatment.
Tissue engineering.
Artificial temporomandibular joints.
Online Access:Abstract with links to full text
Table of Contents:
  • The temporomandibular joint
  • Tissue engineering
  • Anatomy and physiology of the temporomandibular joint
  • Development
  • Etiology, the TMJ healing problem, and age related changes
  • Pathophysiology, catabolism, and osteoarthrosis
  • Guidelines for testing and modeling of tissue mechanics
  • The biomechanical environment of the TMJ
  • Animal models
  • Current therapies
  • Non-invasive treatments
  • Minimally invasive treatments
  • TMJ surgical therapies
  • Invasive surgical therapies, total joint replacement
  • TMJ repair using alloplastic devices
  • Past experiences
  • Currently approved therapies
  • Immune response, immunogenicity, transplants
  • Gender paradox
  • Fibrocartilage of the TMJ disc
  • Introduction
  • Anatomy: structure and attachments
  • Biochemical content
  • Collagen composition and distribution
  • Collagen organization
  • Elastin
  • Proteoglycans and glycosaminoglycans
  • Biomechanical properties
  • Tensile properties
  • Compressive properties
  • Shear and frictional properties
  • Cell types
  • Age-associated changes in the disc
  • Cartilage of the mandibular condyle
  • Introduction
  • Biochemical content
  • Collagen composition and distribution
  • Collagen organization
  • Proteoglycans and glycosaminoglycans
  • Biomechanical properties
  • Tensile and shear properties
  • Compressive properties
  • Cell content
  • Tissue engineering of the disc
  • Introduction
  • Previous tissue engineering efforts
  • Scaffolds
  • Bioactive agents
  • Mechanical stimulation and bioreactors
  • Tissue engineering of the mandibular condyle
  • Introduction
  • Cells of the mandibular condylar cartilage
  • Mandibular condyle tissue engineering studies
  • Current perspectives
  • Cell sources for tissue engineering of cartilage
  • Primary cells
  • Stem cells
  • The joint capsule and the synovium
  • Design standards for tissue engineering
  • Assessments of tissue engineered constructs
  • Directions to improve patient outcomes
  • Bibliography
  • Biography.

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