DNA repair in cancer therapy molecular targets and clinical applications
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| Format: | Electronic |
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London Waltham, MA :
Elsevier/Academic Press,
2012.
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| Edition: | 1st ed. |
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| Online Access: | View fulltext via EzAccess |
Table of Contents:
- Introduction and overview of current targets: bench to clinic / Mark R. Kelley
- 2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu
- 3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto
- 4. PARP inhibitors
- scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew
- 5. Chemotherapy intervention by inhibiting DNA polymerases for therapeutic intervention / Anthony J. Berdis
- 6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick
- 7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle
- 8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller
- 9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li
- 10. DNA repair signaling targets / Susan Ashwell
- 11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis
- 12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan
- 13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko
- 14. Future directions with DNA repair inhibitors / Mark R. Kelley.