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111208s2012 enka b 001 0 eng |
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|a 9780123849991 (eBook)
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|a NLM
|b eng
|c NLM
|d SFB
|d CDX
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|a RC270.8
|b .D53 2012
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| 060 |
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|a QZ 267
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| 245 |
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|a DNA repair in cancer therapy
|b molecular targets and clinical applications
|c edited by Mark R. Kelley.
|h [electronic resource]
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| 250 |
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|a 1st ed.
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| 260 |
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|a London
|a Waltham, MA :
|b Elsevier/Academic Press,
|c 2012.
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| 300 |
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|a 1 online resource xiii, 316 p)
|b ill. ;
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| 504 |
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|a Includes bibliographical references and index.
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| 505 |
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|a Introduction and overview of current targets: bench to clinic / Mark R. Kelley -- 2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu -- 3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto -- 4. PARP inhibitors -- scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew -- 5. Chemotherapy intervention by inhibiting DNA polymerases for therapeutic intervention / Anthony J. Berdis -- 6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick -- 7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle -- 8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller -- 9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li -- 10. DNA repair signaling targets / Susan Ashwell -- 11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis -- 12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan -- 13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko -- 14. Future directions with DNA repair inhibitors / Mark R. Kelley.
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| 650 |
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|a Cancer
|x Treatment
|x Genetic aspects.
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| 650 |
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|a DNA repair.
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| 650 |
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|a Neoplasms
|x drug therapy.
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| 650 |
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|a Neoplasms
|x genetics.
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| 700 |
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|a Kelley, Mark Richard,
|d 1957-
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| 856 |
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|u https://ezaccess.library.uitm.edu.my/login?url=http://www.sciencedirect.com/science/book/9780123849991
|z View fulltext via EzAccess
|