Stress-Induced Mutagenesis

• Corporate Author: SpringerLink (Online service)
• Other Authors: Mittelman, David. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Subjects: Medicine.; Human genetics.; Biochemistry.; Biomedicine.; Human Genetics.; Biochemistry, general.; Biomedicine general.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-6280-4

The discoveries of stress-induced mutation and epigenetic inheritance have challenged the claim of independence between the evolutionary forces of mutation and selection. In Stress-Induced Mutagenesis , leading experts provide the key evidence for and the molecular details of stress-induced genetic...

Table of Contents:

• Preface
• Stress-induced mutagenesis in bacteria
• Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress
• Transcription-mediated mutagenic processes
• Transposon mutagenesis in disease, drug discovery and bacterial evolution
• Hsp90 as a capacitor of both genetic and epigenetic changes in the genome during cancer progression and evolution
• Inheritance of stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors
• Microsatellite Repeats: Canaries in the Coalmine
• Genetic instability Induced by hypoxic stress
• Radiation-induced delayed genome Instability and hypermutation in mammalian cells
• Radiation-induced bystander effects and stress-induced mutagenesis
• Stress induced mutagenesis, genetic diversification, and cell survival via anastasis, the reversal of late stage apoptosis
• The transgenerational effects of parental exposure to mutagens in mammals
• Revisiting mutagenesis in the age of high-throughput sequencing
• Index.