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130321s2013 xxu| s |||| 0|eng d |
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|a 9781461462804
|9 978-1-4614-6280-4
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|a 10.1007/978-1-4614-6280-4
|2 doi
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|a RB155-155.8
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|a QH431
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|a MED107000
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|a 611.01816
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|a 599.935
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|a Mittelman, David.
|e editor.
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|a Stress-Induced Mutagenesis
|c edited by David Mittelman.
|h [electronic resource] /
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2013.
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| 300 |
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|a XV, 275 p. 48 illus., 31 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
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|a text file
|b PDF
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|a Preface -- Stress-induced mutagenesis in bacteria -- Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress -- Transcription-mediated mutagenic processes -- Transposon mutagenesis in disease, drug discovery and bacterial evolution -- Hsp90 as a capacitor of both genetic and epigenetic changes in the genome during cancer progression and evolution -- Inheritance of stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors -- Microsatellite Repeats: Canaries in the Coalmine -- Genetic instability Induced by hypoxic stress -- Radiation-induced delayed genome Instability and hypermutation in mammalian cells -- Radiation-induced bystander effects and stress-induced mutagenesis -- Stress induced mutagenesis, genetic diversification, and cell survival via anastasis, the reversal of late stage apoptosis -- The transgenerational effects of parental exposure to mutagens in mammals -- Revisiting mutagenesis in the age of high-throughput sequencing -- Index.
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|a The discoveries of stress-induced mutation and epigenetic inheritance have challenged the claim of independence between the evolutionary forces of mutation and selection. In Stress-Induced Mutagenesis , leading experts provide the key evidence for and the molecular details of stress-induced genetic and epigenetic mutation, integrating cross-disciplinary observations from a number of species and biological systems, including human. The observations have vast implications for evolutionary biology but also for human medicine. A comprehensive understanding of stress-induced mutagenesis and the processes underlying evolvability, will enable gains in the treatment and management of cancer, as well as other human disorders that result from damaged or unstable genomes.
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| 650 |
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|a Medicine.
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| 650 |
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|a Human genetics.
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| 650 |
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|a Biochemistry.
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| 650 |
1 |
4 |
|a Biomedicine.
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| 650 |
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|a Human Genetics.
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| 650 |
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|a Biochemistry, general.
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| 650 |
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|a Biomedicine general.
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| 710 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9781461462798
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| 856 |
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|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-6280-4
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
|