Natural Products and Cancer Drug Discovery

• Corporate Author: SpringerLink (Online service)
• Other Authors: Koehn, Frank E. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Series: Cancer Drug Discovery and Development
• Subjects: Medicine.; Oncology.; Toxicology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-4654-5

Natural products- compounds derived from plants, microbes and marine organisms, have been an unsurpassed source of cancer drugs in the modern era of drug discovery.� The historical record is strong, but what is the current impact of natural� products in the discovery and development of cancer drugs,...

Table of Contents:

• Preface.-� The Impact of Natural Products upon Cancer Chemotherapy
• Identification and development of vascular disrupting agents: Natural products that interfere with tumor growth
• Discodermolide: Past, Present and Future
• HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents
• Natural Product Cytotoxins As Payloads For Antibody Drug Conjugates
• Natural Product Scaffolds in Cancer Therapy
• The Role of Genetic Engineering in Natural Product-based Anticancer Drug Discovery
• Accessing Anti-Cancer Natural Products by Plant Cell Culture
• Natural Products as Tools for Discovering New Cancer Targets
• Index.