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121116s2013 xxu| s |||| 0|eng d |
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|a 9781461446545
|9 978-1-4614-4654-5
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|a 10.1007/978-1-4614-4654-5
|2 doi
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|a RC261-271
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|a MJCL
|2 bicssc
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|a MED062000
|2 bisacsh
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|a 614.5999
|2 23
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| 100 |
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|a Koehn, Frank E.
|e editor.
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|a Natural Products and Cancer Drug Discovery
|c edited by Frank E. Koehn.
|h [electronic resource] /
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| 264 |
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1 |
|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2013.
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| 300 |
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|a XII, 244 p. 94 illus., 17 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 347 |
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|a text file
|b PDF
|2 rda
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| 490 |
1 |
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|a Cancer Drug Discovery and Development
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| 505 |
0 |
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|a Preface.-� The Impact of Natural Products upon Cancer Chemotherapy -- Identification and development of vascular disrupting agents: Natural products that interfere with tumor growth -- Discodermolide: Past, Present and Future -- HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents -- Natural Product Cytotoxins As Payloads For Antibody Drug Conjugates -- Natural Product Scaffolds in Cancer Therapy -- The Role of Genetic Engineering in Natural Product-based Anticancer Drug Discovery -- Accessing Anti-Cancer Natural Products by Plant Cell Culture -- Natural Products as Tools for Discovering New Cancer Targets -- Index.
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| 520 |
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|a Natural products- compounds derived from plants, microbes and marine organisms, have been an unsurpassed source of cancer drugs in the modern era of drug discovery.� The historical record is strong, but what is the current impact of natural� products in the discovery and development of cancer drugs, and importantly what are the prospects for natural products to be a valuable source of �future agents?� This volume attempts to address this question through a series of chapters authored by leading researchers in the field which effectively provide an in-depth view of several high impact areas of natural products cancer research. The volume begins with a focused analysis and rationale for the clinical success� of current natural product anti-cancer drugs. The following chapters then describe new natural product based drugs in three rapidly evolving target classes and modalities- agents which target tumor vasculature, inhibitors of histone deacetylase and other histone modifying enzymes, and �antibody drug conjugates.� Subsequent chapters examine the central role of natural product chemical scaffolds in the genesis of new anti-cancer therapeutics- first via the powerful application of chemical synthesis, and then through the �rapidly emerging fields of biosynthetic engineering and plant cell culture. �The volume concludes with an assessment of the critical role that natural products continue to play in the search for new cancer drug targets.� As the reader makes his or her way through the volume it may become clear that there is strong evidence that natural products will continue to exert a profound positive impact on cancer drug discovery.
|
| 650 |
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0 |
|a Medicine.
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| 650 |
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0 |
|a Oncology.
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| 650 |
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|a Toxicology.
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| 650 |
1 |
4 |
|a Biomedicine.
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| 650 |
2 |
4 |
|a Cancer Research.
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| 650 |
2 |
4 |
|a Oncology.
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| 650 |
2 |
4 |
|a Pharmacology/Toxicology.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
0 |
8 |
|i Printed edition:
|z 9781461446538
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| 830 |
# |
0 |
|a Cancer Drug Discovery and Development
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| 856 |
4 |
0 |
|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-4654-5
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| 912 |
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|a ZDB-2-SME
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| 950 |
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|a Medicine (Springer-11650)
|