miRNA Regulation of the Translational Machinery

The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencin...

Full description

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Rhoads, Robert E. (Editor)
Format: Electronic
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2010.
Series:Progress in Molecular and Subcellular Biology, 50
Subjects:
Online Access:https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-3-642-03103-8
LEADER 03486nam a22005175i 4500
001 9986
003 DE-He213
005 20130725193420.0
007 cr nn 008mamaa
008 100301s2010 gw | s |||| 0|eng d
020 # # |a 9783642031038  |9 978-3-642-03103-8 
024 7 # |a 10.1007/978-3-642-03103-8  |2 doi 
050 # 4 |a QH345 
050 # 4 |a QD415-436 
072 # 7 |a PSB  |2 bicssc 
072 # 7 |a SCI007000  |2 bisacsh 
082 0 4 |a 572  |2 23 
100 1 # |a Rhoads, Robert E.  |e editor. 
245 1 0 |a miRNA Regulation of the Translational Machinery  |c edited by Robert E. Rhoads.  |h [electronic resource] / 
264 # 1 |a Berlin, Heidelberg :  |b Springer Berlin Heidelberg,  |c 2010. 
300 # # |a X, 115p. 23 illus., 4 illus. in color.  |b online resource. 
336 # # |a text  |b txt  |2 rdacontent 
337 # # |a computer  |b c  |2 rdamedia 
338 # # |a online resource  |b cr  |2 rdacarrier 
347 # # |a text file  |b PDF  |2 rda 
490 1 # |a Progress in Molecular and Subcellular Biology,  |v 50  |x 0079-6484 ; 
505 0 # |a Understanding how miRNAs post-transcriptionally regulate gene expression -- Translational Control of Endogenous MicroRNA Target Genes in C. elegans -- Translational inhibition by microRNAs in Plants -- Regulation of p27kip1 mRNA expression by microRNAs -- The Inhibitory Effect of apolipoprotein B mRNA-editing Enzyme Catalytic Polypeptide-like 3G (APOBEC3G) and Its Family Members on the Activity of Cellular MicroRNAs -- microRNA-mediated mRNA deadenylation and repression of protein synthesis in a mammalian cell-free system -- miRNA effects on mRNA closed-loop formation during translation initiation. 
520 # # |a The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1). 
650 # 0 |a Life sciences. 
650 # 0 |a Gene expression. 
650 # 0 |a Medicine. 
650 # 0 |a Biochemistry. 
650 # 0 |a Cytology. 
650 1 4 |a Life Sciences. 
650 2 4 |a Biochemistry, general. 
650 2 4 |a Cell Biology. 
650 2 4 |a Gene Expression. 
650 2 4 |a Molecular Medicine. 
710 2 # |a SpringerLink (Online service) 
773 0 # |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9783642031021 
830 # 0 |a Progress in Molecular and Subcellular Biology,  |v 50  |x 0079-6484 ; 
856 4 0 |u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-3-642-03103-8 
912 # # |a ZDB-2-SBL 
950 # # |a Biomedical and Life Sciences (Springer-11642)