Adverse Drug Reactions
This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of...
| Corporate Author: | |
|---|---|
| Other Authors: | |
| Format: | Electronic |
| Language: | English |
| Published: |
Berlin, Heidelberg :
Springer Berlin Heidelberg,
2010.
|
| Series: | Handbook of Experimental Pharmacology,
196 |
| Subjects: | |
| Online Access: | https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-3-642-00663-0 |
Table of Contents:
- Part I. Target Organ Toxicity
- Drug-Induced Liver Injury. Drug Hypersensitivity Reactions Involving Skin. Adverse Drug Reactions Affecting Blood Cells. Molecular Mechanisms of Adverse Drug. Reactions in Cardiac Tissue. Nephrotoxicity Receptor- and Reactive Intermediate-Mediated Mechanisms of Teratogenesis
- Part II. Mediators/Biochemical Pathways
- Role of Reactive Metabolites in Drug-Induced Hepatotoxicity. The Role of Cytokines in the Mechanism of Adverse Drug Reactions. The Keap1-Nrf2 Cellular Defence Pathway. Signal Transduction Pathways Involved in Drug-Induced Liver Injury. Mitochondrial Involvement in Drug-Induced Liver Injury
- Part III. Examples/Models
- Mechanisms of Acetaminophen-Induced. Liver Necrosis. Drug-Induced Liver Injury in Humans: The Case of Ximelagatran. Troglitazone. Nevirapine Hypersensitivity. Mechanisms of Adverse Drug Reactions to Biologics
- Part IV. Risk Factors/Screening Drug Candidates
- Pharmacogenetics of Idiosyncratic Adverse Drug Reactions. The Danger Hypothesis Applied to Idiosyncratic Drug Reactions. Approaches for Minimizing Metabolic Activation of New Drug Candidates in Drug Discovery.