Myeloma Bone Disease

This state-of-the-art book presents the forefront in the science and clinical management of myeloma bone disease. Assembling the work of the world's premier thought leaders, this book begins with sections on clinical presentation, imaging, and biochemical markers and then goes on to discuss rad...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Roodman, G. David. (Editor)
Format: Electronic
Language:English
Published: Totowa, NJ : Humana Press, 2010.
Series:Current Clinical Oncology
Subjects:
Online Access:https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-60761-554-5
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505 0 # |a Clinical presentation of myeloma bone disease (MBD) -- Imaging of myeloma bone disease -- Bone Markers in MBD -- Radiation therapy for MBD -- Surgical treatment (kyphoplasty, vertebroplasty and standard surgery) -- Pathophysiology of MBD -- Osteoclast activation in MBD -- Osteoblast Suppression in MBD -- Animal models of MBD -- Bisphopsphonate treatment of MBD -- Osteonecrosis of the jaw in myeloma -- Novel therapies for MBD (Denosumab, velcade and imids). 
520 # # |a This state-of-the-art book presents the forefront in the science and clinical management of myeloma bone disease. Assembling the work of the world's premier thought leaders, this book begins with sections on clinical presentation, imaging, and biochemical markers and then goes on to discuss radiation, surgical, and medical therapies. Specific chapters are devoted to bisphosphonates and novel therapeutic agents, such as RANKL inhibitors, Wnt signaling inhibitors, and IMiDs. The mechanisms of osteoclast activation and osteoblast suppression in multiple myeloma are also explored. Myeloma Bone Disease is a valuable resource for medical, surgical, and radiation oncologists and cancer researchers. 
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