Protein Kinase C in Cancer Signaling and Therapy
Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980s with its identification as an effector of phorbol esters, natural products with tumor-promoting activity. Phorbol esters had long been of interest to the cancer re...
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| Format: | Electronic |
| Language: | English |
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Totowa, NJ :
Humana Press : Imprint: Humana Press,
2010.
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| Series: | Current Cancer Research
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| Subjects: | |
| Online Access: | https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-60761-543-9 |
Table of Contents:
- Protein Kinase C in Cancer Signaling and Therapy, Introduction and Historical Perspective
- Regulation of conventional and novel protein kinase C isozymes by phosphorylation and lipids
- Phorbol esters and diacylglycerol: the PKC activators
- Diacylglycerol signaling: the C1 domain, generation of DAG and termination of signals
- Regulation of PKC by protein-protein interactions in cancer
- Introduction: PKC isozymes in the control of cell function
- Regulation and function of protein kinase D signaling
- PKC and control of the cell cycle
- PKC and the control of apoptosis
- Atypical PKCs, NF-kB and inflammation
- Introduction, PKC isozymes in cancer
- PKC, p53, and DNA damage
- PKCs as mediators of the Hedgehog and Wnt pathways
- PKC-PKD interplay in cancer
- Transgenic mouse models to investigate functional specificity of protein kinase C isoforms in the development of squamous cell carcinoma, a non-melanoma human skin cancer
- PKC isozymes and skin cancer
- PKC isozymes and breast cancer
- PKC and prostate cancer
- PKC and lung cancer
- Introduction, PKC isozymes as targets for cancer therapy
- PKC and resistance to chemotherapeutic agents
- PKCd as a target for chemotherapeutic drugs
- Atypical PKCs as targets for cancer therapy.