Cancer and IgE Introducing the Concept of AllergoOncology /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Penichet, Manuel L. (Editor), Jensen-Jarolim, Erika. (Editor)
• Format: Electronic
• Language: English
• Published: Totowa, NJ : Humana Press, 2010.
• Subjects: Medicine.; Oncology.; Immunology.; Biomedicine.; Cancer Research.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-60761-451-7

Allergies are caused by a persons own IgE antibodies directed against innocuous antigens like pollen or house dust mites. Interestingly, several studies have examined the relation between allergies or level of IgE and malignancies and have found an inverse association suggesting a natural role of I...

Table of Contents:

• Introduction
• The biology of IgE: molecular mechanism restraining potentially dangerous high serum IgE titres in vivo.-The biology of IgE: the generation of high affinity IgE antibodies
• Epidemiological evidence: IgE, atopy and aolid tumors
• Epidemiological evidence: IgE, allergies, and hematopoietic malignancies
• Mast cells in allergy and tumor disease
• The IgE antibody and its use in cancer immunotherapy
• IgE interacts with potent effector cells against tumors: ADCC and ADCP
• IgE as adjuvant in tumor vaccination
• The targets of IgE: allergen-associated and tumor-associated molecular patterns (AAMPs and TAMPs)
• The role of Th2-mediated anti-tumor immunity in tumor surveillance and clearance.