p53

• Main Authors: Ayed, Ayeda. (Author), Hupp, Theodore. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic
• Language: English
• Published: Boston, MA : Springer US : Imprint: Springer, 2010.
• Series: Molecular Biology Intelligence Unit, 1
• Subjects: Medicine.; Oncology.; Biomedicine.; Cancer Research.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-8231-5

This volume, p53, was developed primarily as a resource for access to key ideas in the field that have developed over the years including how transgenics have been used to study p53, how clinical genetics have identified and studied mutations in p53 found in human cancers, how p53 can be regulated b...

Table of Contents:

• TP53 Mutations in Human Cancers: Selection versus Mutagenesis
• Lessons on p53 from Mouse Models
• TP63, TP73: The Guardians Elder Brothers
• The Regulation of p53 Protein Function by Phosphorylation
• The p53-Mdm2 Loop: A Critical Juncture of Stress Response
• Cooperation between MDM2 and MDMX in the Regulation of p53
• Regulation and Function of the Original p53-Inducible p21 Gene
• p53 Localization
• Modes of p53 Interactions with DNA in the Chromatin Context
• p53s Dilemma in Transcription: Analysis by Microarrays
• Tumor Viruses and p53
• p53 and Immunity.