Protein Metabolism and Homeostasis in Aging

• Corporate Author: SpringerLink (Online service)
• Other Authors: Tavernarakis, Nektarios. (Editor)
• Format: Electronic
• Language: English
• Published: Boston, MA : Springer US, 2010.
• Series: Advances in Experimental Medicine and Biology, 694
• Subjects: Medicine.; Biomedicine.; Biomedicine general.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-7002-2

The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, posttranslational modifications, degradation and turnover, and how they define and influence aging. T...

Table of Contents:

• Synthesis, Modification and Turnover of Proteins during Aging
• Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control
• Protein Synthesis and the Antagonistic Pleiotropy Hypothesis of Aging
• Proteasome Function Determines Cellular Homeostasis and the Rate of Aging
• Autophagy and Longevity: Lessons from C. elegans
• Autophagy and Aging: Lessons from Progeria Models
• Regulation of Protein Turnover by Longevity Pathways
• Protein Metabolism and Lifespan in Caenorhabditis elegans
• Mitochondrial Protein Quality Control Systems in Aging and Disease
• p38MAPK in the Senescence of Human and Murine Fibroblasts
• Protein Homeostasis in Models of Aging and AgeRelated Conformational Disease
• Roles for SUMO Modification during Senescence
• PostTranslational Modification of Cellular Proteins by Ubiquitin and UbiquitinLike Molecules: Role in Cellular Senescence and Aging
• Sensory Influence on Homeostasis and Lifespan: Molecules and Circuits
• Regulation of Muscle Atrophy in Aging and Disease
• Confronting Cellular Heterogeneity in Studies of Protein Metabolism and Homeostasis in Aging Research.