Cell Cycle Deregulation in Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Enders, Greg H. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York, 2010.
• Series: Current Cancer Research
• Subjects: Medicine.; Oncology.; Toxicology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-1770-6

Modern studies of regulation of the cell division cycle were pioneered by Leland Hartwell, Paul Nurse, and Tim Hunt in yeast and marine invertebrates. This work identified proteins termed cyclins that fluxuate in abundance during progression through the cycle and partner with Cyclin dependent kinase...

Table of Contents:

• Escape from cellular quiescence
• Interplay between Cyclin-dependent Kinases and E2F-dependent Transcription
• Regulation of pre-RC assembly: A complex symphony orchestrated by CDKs
• Mitotic checkpoint and chromosome instability in cancer
• Mitotic catastrophe
• p53, ARF and the control of autophagy
• Regulation of self-renewing divisions in normal and leukaemia stem cells
• Maintenance of Telomeres in Cancer
• The senescence secretome and its impact on tumor suppression and cancer
• Cell cycle deregulation in pre-neoplasia: case study of Barretts esophagus
• Targeting cyclin dependent kinases for cancer therapy.-.