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Structure and Function of the Neural Cell Adhesion Molecule NCAM

Adhesive interactions are important for cell trafficking, differentiation, function and tissue formation. In the nervous system, many cell adhesion molecules (CAMs) are involved in migration of neuroblasts, outgrowth and fasciculation of neuronal processes, formation of synapses and rearrangements o...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Berezin, Vladimir. (Editor)
Format: Electronic
Language:English
Published: New York, NY : Springer New York, 2010.
Series:Advances in Experimental Medicine and Biology, 663
Subjects:
Medicine.
Human physiology.
Neurosciences.
Neurochemistry.
Neurobiology.
Biomedicine.
Human Physiology.
Online Access:https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-1170-4
Table of Contents:
  • Structure and Ligands of NCAM.Structural Biology of NCAM.Extracellular Protein Interactions Mediated by NCAM: Heterophilic Interactions between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses.Intracellular Ligands of NCAM.NCAM and the FGF receptor.The Role of ATP in the Regulation of NCAM Function
  • NCAM and Polysialic Acid.Polysialylation of NCAM.Structural Basis for the Polysialylation of NCAM.The Role of PSA-NCAM in Adult Neurogenesis.Use of PSA-NCAM in Repair of the Central Nervous System
  • NCAM-mediated Signal Transduction.Signaling Pathways Involved in NCAM-induced Neurite Outgrowth.Role of Growth-Associated Protein GAP-43 in NCAM-mediated Neurite Outgrowth.NCAM and Lipid Rafts.NCAM and Epidermal Growth Factor Receptor: Signaling Crosstalk
  • NCAM Metabolism.Biosynthesis of NCAM.Soluble NCAM
  • NCAM, Synapses, Emotions, and Memory.Role of NCAM in Spine Dynamics and Synaptogenesis.NCAM in Long-term Potentiation and Learning.Role of NCAM in Emotion and Learning
  • NCAM in Disease.NCAM in Neuropsychiatric and Neurodegenerative Disorders.NCAM in Cancer: Expression and Mechanisms
  • Pharmacology of NCAM: NCAM Mimetics.NCAM Mimetic Peptides: An Update.Synthetic NCAM-derived Ligands of the FGF receptor.Dendritic Spine and Synapse Morphological Alterations Induced by an NCAM Mimetic
  • Orthologs and Paralogs of NCAM.Fasciclin II: The NCAM Ortholog in Drosophila melanogaster.The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM: A Close Relative of NCAM
  • Conclusion.Honoring Dr. Elisabeth Bock.

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