Cellular Senescence and Tumor Suppression

• Corporate Author: SpringerLink (Online service)
• Other Authors: Adams, Peter D. (Editor), Sedivy, John M. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York, 2010.
• Subjects: Medicine.; Oncology.; Human genetics.; Toxicology.; Biomedicine.; Cancer Research.; Human Genetics.; Pharmacology/Toxicology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-1075-2

Leonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, sho...

Table of Contents:

• Telomere biology and biochemistry
• Short telomere-driven senescence
• Oncogene-induced senescence
• Stress-induced senescence
• Modulation of senescence by extracellular growth factors
• The senescent phenotype and its evolution
• Chromatin structure in senescent cells
• A comparison of senescence in mouse and human cells
• Tumor suppression
• Tissue aging
• Senescence as a potential therapeutic tool.