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100601s2010 xxu| s |||| 0|eng d |
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|a 9781441910448
|9 978-1-4419-1044-8
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|a 10.1007/978-1-4419-1044-8
|2 doi
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|a 571.4
|2 23
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| 100 |
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|a Frauenfelder, Hans.
|e author.
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| 245 |
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|a The Physics of Proteins
|b An Introduction to Biological Physics and Molecular Biophysics /
|c by Hans Frauenfelder ; edited by Shirley S. Chan, Winnie S. Chan.
|h [electronic resource] :
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| 264 |
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1 |
|a New York, NY :
|b Springer New York,
|c 2010.
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| 300 |
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|a XV, 448p. 221 illus., 7 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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| 347 |
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|a text file
|b PDF
|2 rda
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| 490 |
1 |
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|a Biological and Medical Physics, Biomedical Engineering,
|x 1618-7210
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| 505 |
0 |
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|a Part I: Biomolecules -- The Hierarchy of Living Things -- Information and Function -- Biomolecules, Spin Glasses, Glasses, and Solids -- Proteins -- Nucleic Acids -- The Genetic Code -- Lipids and Membranes -- Part II: Spatial Structure of Proteins: Measurementand Consequence -- Scattering of Photons for Imaging: Diffraction and Microscopy -- X-Ray Diffraction -- Pulsed Nuclear Magnetic Resonance and Molecular Structure Determination in Solution -- The Secondary Structure -- Tertiary Structure of Proteins -- Myoglobin and Hemoglobin -- Part III: The Entergylandscape and Dynamics of Proteins -- Conformational Substates -- The Organization of the Energy Landscape -- Reaction Theory -- Supercooled Liquids and Glasses -- Part IV: Function and Dynamics -- Part V: Appendices: Tools to Study the Physics of Proteins.
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| 520 |
# |
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|a Physics and the life sciences have established new connections within the past few decades, resulting in biological physics as an established subfield with strong groups working in many physics departments. These interactions between physics and biology form a two-way street with physics providing new tools and concepts for understanding life, while biological systems can yield new insights into the physics of complex systems. To address the challenges of this interdisciplinary area, The Physics of Proteins: An Introduction to Biological Physics and Molecular Biophysics is divided into three interconnected sections. In Parts I and II, early chapters introduce the terminology and describe the main biological systems that physicists will encounter. Similarities between biomolecules, glasses, and solids are stressed with an emphasis on the fundamental concepts of living systems. The central section (Parts III and IV) delves into the dynamics of complex systems. A main theme is the realization that biological systems, in particular proteins, do not exist in unique conformations but can assume a very large number of slightly different structures. This complexity is captured in the concept of a free energy landscape and leads to the conclusion that fluctuations are crucial for the functioning of biological systems. The final chapter of this section challenges the reader to apply these concepts to a problem that appears in the current literature. An extensive series of appendices (Part V) provide descriptions of the key physical tools and analytical methods that have proven powerful in the study of the physics of proteins. The appendices are designed to be consulted throughout the section on protein dynamics without breaking the deductive flow of the logic in the central section of the book.
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| 650 |
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|a Physics.
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|a Medicine.
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| 650 |
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|a Biochemistry.
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| 650 |
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|a Proteomics.
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| 650 |
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|a Biomedical engineering.
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| 650 |
1 |
4 |
|a Physics.
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| 650 |
2 |
4 |
|a Biophysics and Biological Physics.
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| 650 |
2 |
4 |
|a Biochemistry, general.
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| 650 |
2 |
4 |
|a Biomedical Engineering.
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| 650 |
2 |
4 |
|a Biomedicine general.
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| 650 |
2 |
4 |
|a Proteomics.
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| 700 |
1 |
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|a Chan, Shirley S.
|e editor.
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| 700 |
1 |
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|a Chan, Winnie S.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
0 |
8 |
|i Printed edition:
|z 9781441910431
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| 830 |
# |
0 |
|a Biological and Medical Physics, Biomedical Engineering,
|x 1618-7210
|
| 856 |
4 |
0 |
|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-1044-8
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| 912 |
# |
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|a ZDB-2-PHA
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| 950 |
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|a Physics and Astronomy (Springer-11651)
|