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Enzyme- and Transporter-Based Drug-Drug Interactions Progress and Future Challenges /

This volume is authored by esteemed experts in the field, and provides state-of-the art knowledge related to enzyme- and transporter-based DDIs that impact the absorption and disposition of drugs. It examines the types of DDIs, methodological approaches to evaluate and view DDIs mechanistically, bio...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Pang, K. Sandy. (Editor), Rodrigues, A. David. (Editor), Peter, Raimund M. (Editor)
Format: Electronic
Language:English
Published: New York, NY : Springer New York, 2010.
Edition:1.
Subjects:
Medicine.
Toxicology.
Analytical biochemistry.
Biochemistry.
Biomedicine.
Pharmacology/Toxicology.
Analytical Chemistry.
Medicinal Chemistry.
Online Access:https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-0840-7
Table of Contents:
  • Enzymatic Basis Of Phase I And Phase II Drug Metabolism
  • Transporters: Importance In Drug Absorption, Distribution And Elimination
  • ADME Pharmacogenetics and Its Impact on Drug-Drug Interactions
  • Impact Of Nuclear Receptors, CAR, PXR, FXR, And VDR, And Their Ligands On Enzymes And Transporters
  • Impact of Physiological Determinants: Flow, Binding, Transporters And Enzymes On Organ and Total Body Clearances
  • In Silico Approaches to Predict Drug-Drug Interactions
  • In Vitro Techniques To Study Drug-Drug Interactions Of Drug Metabolism: Cytochrome P450
  • In Vitro Characterization Of Inhibitory Drug-Drug Interactions Involving UDP-Glucuronosyltransferase
  • In Vitro Techniques To Study Transporter-Based Drug-Drug Interactions
  • In Vitro Techniques To Study Drug-Drug Interactions Involving Transport: Caco-2 Model For Study Of P-Glycoprotein And Other Transporters
  • Use Of In Vivo Animal Models To Assess Drug-Drug Interactions
  • Extrapolation of In Vitro Metabolic and P-Glycoprotein-mediated Transport Data To In Vivo By Modeling and Simulations
  • Translation Of In Vitro Metabolic Data To Predict In Vivo Drug-Drug Interactions: IVIVE And Modeling And Simulations
  • Absorption Models To Examine Bioavailability And DDI<U+0019>s In Humans
  • Management Of Drug Interactions Of New Drugs In Multicenter Trials Using The Metabolism & Transport Drug Interaction Database♭
  • Web-Based Database As A Tool To Examine Drug-Drug Interactions Involving Transporters
  • Drug Disposition And Drug-Drug Interactions: Importance Of First-Pass Metabolism In Gut And Liver
  • Transporter Based Drug-Drug Interactions And Their Effect On Distribution Volumes
  • Inactivation Of Human Cytochrome P450 Enzymes And Drug-Drug Interactions
  • Allosteric Enzyme And Transporter Based Interactions
  • Interplay Of Transporter-Drug Interaction: Complications Of Both Inhibitory And Inductive Events In Drug-Drug Interaction
  • Herbal Supplement-Based Interactions
  • Anticipating And Minimizing Drug Interactions In A Drug Discovery And Development Setting: Industrial Perspective
  • Clinical Studies Of Drug-Drug Interactions: Design And Interpretation
  • Toxicological Consequences Of Drug-Drug Interactions
  • Complex Drug Interactions: Significance And Evaluation
  • DDI: Labeling And Marketing Perspectives
  • Drug-Drug Interactions: What Have We Learnt And Where Are We Going?.

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