Principles of Clinical Cancer Genetics A Handbook from the Massachusetts General Hospital /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Chung, Daniel C. (Editor), Haber, Daniel A. (Editor)
• Format: Electronic
• Language: English
• Published: Boston, MA : Springer US : Imprint: Springer, 2010.
• Subjects: Medicine.; Human genetics.; Oncology.; Medicine & Public Health.; Human Genetics.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-0-387-93846-2

Advances in genetics are transforming estimates of an individuals risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a c...

Table of Contents:

• Basic principles of cancer genetics
• Principles of Cancer Genetic Counseling and Genetic Testing
• Genetics of Hereditary Breast Cancer
• Surgical management of Hereditary Breast and Ovarian Cancer
• Hereditary colon cancer: Colonic Polyposis Syndromes
• Hereditary colon cancer: Lynch Syndrome
• Hereditary Pancreatic Cancer
• Hereditary Diffuse Gastric Cancer
• Familial Renal Cell Cancers and Pheochromocytomas
• Familial Atypical Mole Melanoma (FAMM) Syndrome
• Multiple Endocrine Neoplasia
• Pediatric malignancies: Retinoblastoma and Wilms tumor
• Neurofibromatosis and Schwannomatosis
• The Hap Map project and low penetrance cancer susceptibility alleles
• Somatic genetic alterations and implications for targeted therapies in cancer (GIST, CML, Lung cancer).