Current Trends in Monoclonal Antibody Development and Manufacturing

• Corporate Author: SpringerLink (Online service)
• Other Authors: Shire, Steven J. (Editor), Gombotz, Wayne. (Editor), Bechtold-Peters, Karoline. (Editor), Andya, James. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2010.
• Series: Biotechnology: Pharmaceutical Aspects ; XI
• Subjects: Medicine.; Neurosciences.; Toxicology.; Biomedicine.; Pharmacology/Toxicology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-0-387-76643-0

Monoclonal antibodies represent one of the fastest growing areas of new drug development within the pharmaceutical industry. Several blockbuster products have been approved over the past several years including Rituxan, Remicade, Avastin, Humira, and Herceptin. In addition, over 300 new drugs are cu...

Table of Contents:

• Introduction
• Design of Therapeutic Monoclonal Antibodies
• Manufacturing of Monoclonal Antibodies/Expression and Production of Monoclonal Antibodies
• Manufacturing of Monoclonal Antibodies/ Recovery and Purification of Bulk Drug Substance
• Formulation and Delivery Challenges
• Analytics and Specification Setting of MAbs
• Pharmacokinetics of Mabs
• Clinics and Toxicology
• Future Trends.