Design and Analysis of Vaccine Studies

• Main Authors: Halloran, M. Elizabeth. (Author), Longini, Jr., Ira M. (Author), Struchiner, Claudio J. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York, 2010.
• Series: Statistics for Biology and Health,
• Subjects: Statistics.; Emerging infectious diseases.; Statistics for Life Sciences, Medicine, Health Sciences.; Infectious Diseases.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-0-387-68636-3

Widespread immunization has many different kinds of effects in individuals and populations, including in the unvaccinated individuals. The challenge is in understanding and estimating all of these effects. This book presents a unified conceptual framework of the different effects of vaccination at t...

Table of Contents:

• Introduction and examples
• Overview of vaccine effects and study designs
• Immunology and early phase trials
• binomial and stochastic transmission models
• R0 and deterministic models
• Evaluating protective effects of vaccination
• Modes of action and time-varying VES
• Further Evaluation of Protective Effects
• Vaccine effects on post-infection outcomes
• House-hold based studies
• Analysis of households in communities
• Analysis of independent households
• Assessing Indirect, total and overall effects
• Randomization and baseline transmission
• Surrogates of protection.