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From Molecules to Medicines Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism /

The synergism played by crystallography and drug discovery is the central focus of this volume which comprises papers presented at the 40th Erice Course held from 28 May to 8 June 2008. A key theme throughout the book is the dependence of modern structural science on multiple experimental and comput...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Sussman, Joel L. (Editor), Spadon, Paola. (Editor)
Format: Electronic
Language:English
Published: Dordrecht : Springer Netherlands, 2009.
Series:NATO Science for Peace and Security Series A: Chemistry and Biology,
Subjects:
Physics.
Computer simulation.
Biochemistry.
RNA-ligand interactions.
Bioinformatics.
Crystallography.
Protein-Ligand Interactions.
Simulation and Modeling.
Protein Structure.
Online Access:https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-90-481-2339-1
Table of Contents:
  • Preface. List of Contributors. Surface Proteins of Gram-Positive Pathogens: Using Crystallography to Uncover Novel Features in Drug and Vaccine Candidates
  • The Rapid Crystallization Strategy for Structure-Based Inhibitor Design
  • Fragment-Based Drug Discovery in Academia: Experiences from a Tuberculosis Programme
  • Structural Biology Contributions to the Discovery of Drugs to Treat Chronic Myelogenous Leukemia
  • Integrating Crystallography Into Early Metabolism Studies
  • The Foundations of Protein-Ligand Interaction
  • Structure-Based Design of TRNA-Guanine Transglycosylase Inhibitors
  • Progress on New Hepatitis C Virus Targets: NS2 and NS5A
  • Protein Structure Modeling.-Structural Biology and Molecular Modeling in the Design of Novel DPP-4 Inhibitors
  • Tools to Make 3D Structural Data More Comprehensible: Emovie & Proteopedia
  • Structural Studies on Acetylcholinesterase and Paraoxonase Directed Towards Development of Therapeutic Biomolecules for the Treatment of Degenerative Diseases and Protection against Chemical Threat Agents
  • Protein Function Prediction from Structure in Structural Genomics and Its Contribution to the Study of Health and Disease
  • Crystal Structures of the <U+00df>2-Adrenergic Receptor
  • Can Structures lead to better Drugs? Lessons from Ribosome Research.-.

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