The Hygiene Hypothesis and Darwinian Medicine

• Corporate Author: SpringerLink (Online service)
• Other Authors: Rook, Graham A. W. (Editor)
• Format: Electronic
• Language: English
• Published: Basel : Birkhũser Basel, 2009.
• Series: Progress in Inflammation Research
• Subjects: Medicine.; Immunology.; Microbiology.; Emerging infectious diseases.; Cytology.; Biomedicine.; Infectious Diseases.; Medical Microbiology.; Cell Biology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-3-7643-8903-1

Man has moved rapidly from the hunter-gatherer environment to the living conditions of the rich industrialised countries. The hygiene hypothesis suggests that the resulting changed and reduced pattern of exposure to micro-organisms has led to disordered regulation of the immune system, and hence to...

Table of Contents:

• Introduction: The changing microbial environment, Darwinian medicine and the hygiene hypothesis
• The paleolithic disease-scape, the hygiene hypothesis, and the second epidemiological transition
• Immunoregulation by microbes and parasites in the control of allergy and autoimmunity
• Hepatitis A virus, TIM-1 and allergy
• Linking lifestyle with microbiota and risk of chronic inflammatory disorders
• Soil bacteria, nitrite and the skin
• The hygiene hypothesis and allergic disorders
• Multiple sclerosis
• Inflammatory bowel disease and the hygiene hypothesis: an argument for the role of helminths
• The hygiene hypothesis and Type 1 diabetes
• The hygiene hypothesis and affective and anxiety disorders
• Immune regulation in atherosclerosis and the hygiene hypothesis
• The <U+0018>delayed infection<U+0019> (aka <U+0018>hygiene<U+0019>) hypothesis for childhood leukaemia
• Is there room for Darwinian medicine and the hygiene hypothesis in Alzheimer pathogenesis?- Alternative and additional mechanisms to the hygiene hypothesis.