Molecular, Clinical and Environmental Toxicology Volume 1: Molecular Toxicology /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Luch, Andreas. (Editor)
• Format: Electronic
• Language: English
• Published: Basel : Birkhũser Basel, 2009.
• Series: Experientia Supplementum, 99
• Subjects: Medicine.; Toxicology.; Biomedicine.; Pharmacology/Toxicology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-3-7643-8336-7

Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, t...

Table of Contents:

• Historical milestones and discoveries that shaped the toxicology sciences
• Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment
• The role of biotransformation and bioactivation in toxicity
• Genotoxicity: damage to DNA and its consequences
• Role of DNA repair in the protection against genotoxic stress
• On the impact of the molecule structure in chemical carcinogenesis
• Chemical induced alterations in p53 signaling
• Molecular pathways involved in cell death after chemically induced DNA damage
• The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways
• Mapping the epigenome <U+0013> impact for toxicology
• Receptors mediating toxicity and their involvement in endocrine disruption
• Toxicogenomics: transcription profiling for toxicology assessment
• The role of toxicoproteomics in assessing organ specific toxicity
• High-throughput screening for analysis of in vitro toxicity.