Intracellular Traffic and Neurodegenerative Disorders

• Corporate Author: SpringerLink (Online service)
• Other Authors: George-Hyslop, Peter H. St. (Editor), Mobley, William C. C. (Editor), Christen, Yves. (Editor)
• Format: Electronic
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2009.
• Series: Research and Perspectives in Alzheimer's Disease,
• Subjects: Medicine.; Neurosciences.; Biomedicine.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-3-540-87941-1

This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the...

Table of Contents:

• Amyloid precursor protein sorting and processing: transmitters, hormones, and protein phosphorylation mechanisms
• Intramembrane proteolysis by gamma-secretase and signal peptide peptidases
• Axonal transport and neurodegenerative disease
• Simple cellular solutions to complex problems
• Tau and intracellular transport in neurons
• Signaling between synapse and nucleus during synaptic plasticity
• Axonal transport of neurotrophic signals: an Achilles heel for neurodegeneration?- Membrane trafficking and targeting in Alzheimers disease
• Huntingtons disease: function and dysfunction of huntingtin in axonal transport
• The role of retromer in neurodegenerative disease
• Regulation of endocytic trafficking of receptors and transporters by ubiquitination: possible role in neurodegenerative disease
• The sortilin-related receptor SORL1 is functionally and genetically associated with Alzheimers disease
• Regulation of transport and processing of amyloid precursor protein by THE sorting receptor sorLA
• Subject index.