Elements of Synthesis Planning

• Main Author: Hoffmann, R.W. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2009.
• Edition: 1.
• Subjects: Chemistry.; Chemistry, Organic.; Biochemistry.; Organic Chemistry.; Medicinal Chemistry.; Biochemistry, general.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-3-540-79220-8

The total synthesis of compounds with interesting physical or biological properties is at the core of organic chemistry. Since only a small number of such compounds originate from natural sources, devising de novo routes to unique and artificial scaffolds requires the skills of planning and executin...

Table of Contents:

• Introduction
• Functional Group Oriented Bond-Sets
• Skeleton Oriented Bond-Sets
• Building Block Oriented Synthesis
• The Basis for Planning
• Formation of Cyclic Structures
• Protecting Groups
• Ranking of Synthesis Plans
• Computer-Aided Synthesis Planning
• Stereogenic Centers and Planning of Syntheses
• Enjoying the Art of Synthesis
• Summary and Concluding Remarks
• Solutions to Problems.