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100301s2009 xxu| s |||| 0|eng d |
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|a 9781603275798
|9 978-1-60327-579-8
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|a 10.1007/978-1-60327-579-8
|2 doi
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|a RC321-580
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|a PSAN
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|a MED057000
|2 bisacsh
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|a 612.8
|2 23
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|a Haddad, Gabriel G.
|e editor.
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|a Brain Hypoxia and Ischemia
|b with Special Emphasis on Development /
|c edited by Gabriel G. Haddad, Shan Ping Yu.
|h [electronic resource] :
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|a Totowa, NJ :
|b Humana Press,
|c 2009.
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| 300 |
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|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a text file
|b PDF
|2 rda
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| 490 |
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|a Contemporary Clinical Neuroscience
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|a Hybernation and CNS survival -- High CO2 and ischemia -- ROS and brain injury in ischemia -- Apoptotic surface delivery of K+ channels -- Intermittent low O2 and brain function -- Mechainsms of injury and survival in hypoxia and ischemia in the CNS -- Regulation of apoptotic volume decrease and apoptosis by plasma membrane aquaporin activity -- Mitochondrial mechanisms in ischemia/hypoxia -- Blood flow and hypoxia/ischemia in CNS -- Mitochondrial permeability transition and cell death -- Neurodegeneration and hypoxia/ischemia -- Glutamate and NO in the CNS -- HIF and brain hypoxia -- Calcium-permeable acid-sensing ion channels in brain ischemia -- Regulation of ion channels and receptors in brain ischemia -- Factors influencing cell death in the penumbra -- Critical roles of Na+,K+-ATPase in apoptosis and CNS diseases -- Mechanisms of tolerance/susceptibility in the CNS -- SIDS and PVL/prematurity and white matter injury.
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|a Brain Hypoxia and Ischemia Gabriel G. Haddad, M.D. and Shan Ping Yu, M.D., Ph.D., Editors Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development. This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice. Gabriel G. Haddad, M.D. is Professor of Pediatrics and Neuroscience and Chair of the Department of Pediatrics at the University of California, San Diego. He is also Physician-in-Chief at Rady Children s Hospital in San Diego. Shan Ping Yu, M.D., Ph.D. is Professor of Anesthesiology at Emory University in Atlanta, GA.
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| 650 |
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|a Medicine.
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| 650 |
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|a Human physiology.
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| 650 |
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|a Neurosciences.
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| 650 |
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|a Neurology.
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| 650 |
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|a Neurobiology.
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| 650 |
1 |
4 |
|a Biomedicine.
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| 650 |
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4 |
|a Neurosciences.
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| 650 |
2 |
4 |
|a Neurology.
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| 650 |
2 |
4 |
|a Neurobiology.
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| 650 |
2 |
4 |
|a Human Physiology.
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| 700 |
1 |
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|a Yu, Shan Ping.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9781603275781
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| 830 |
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|a Contemporary Clinical Neuroscience
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| 856 |
4 |
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|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-60327-579-8
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| 912 |
# |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
|