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APC Proteins

The initial identification of the Adenomatous polyposis coli (Apc) gene as the site of mutations in familial adenomatous polyposis (FA P) was described in 1992. A causal relationship between Apc mutations and intestinal tract tumours was confirmed three years later with the establishment of the Min...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Nt̃hke, Inke S. (Editor), McCartney, Brooke M. (Editor)
Format: Electronic
Language:English
Published: New York, NY : Springer New York, 2009.
Series:Advances in Experimental Medicine and Biology, 656
Subjects:
Medicine.
Biomedicine.
Biomedicine general.
Online Access:https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-1145-2
Table of Contents:
  • APC and <U+00df>-Catenin Degradation
  • Nuclear APC
  • APC in Cell Migration
  • The APC-EB1 Interaction
  • The Role of APC in Mitosis and in Chromosome Instability
  • Role of APC and its Binding Partners in Regulating Microtubules in Mitosis
  • The Adenomatous Polyposis Coli Tumor Suppressor and Wnt Signaling in the Regulation of Apoptosis
  • APC and Its Modifiers in Colon Cancer
  • Tissue-Specific Tumour Suppression by APC
  • Extra-Colonic Manifestations of Familial Adenomatous Polyposis Coli.

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