Mathematics of DNA Structure, Function and Interactions

Propelled by the success of the sequencing of the human and many related genomes, molecular and cellular biology has delivered significant scientific breakthroughs. Mathematics (broadly defined) continues to play a major role in this effort, helping to discover the secrets of life by working collabo...

Full description

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Benham, Craig John. (Editor), Harvey, Stephen. (Editor), Olson, Wilma K. (Editor), Sumners, De Witt. (Editor), Swigon, David. (Editor)
Format: Electronic
Language:English
Published: New York, NY : Springer New York, 2009.
Series:The IMA Volumes in Mathematics and its Applications, 150
Subjects:
Online Access:https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-0670-0
Table of Contents:
  • Foreword
  • Preface
  • Nick Cozzarelli: A personal remembrance
  • Mathematical methods in DNA topology: Applications to chromosome organization and site-specific recombination
  • Conformational statistics of DNA and diffusion equations on the Euclidean group
  • Perspectives on DNA looping
  • Differences between positively and negatively supercoiled DNA that topoisomerases may distinguish
  • Calibration of tethered particle motion experiments
  • Difference topology: Analysis of high-order DNA-protein assemblies
  • Useful intrusions of DNA topology into experiments on protein-DNA geometry
  • Topological analysis of DNA-protein complexes
  • Closing the loop on protein-DNA interactions: Interplay between shape and flexibility in nucleoprotein assemblies having implications for biological regulation
  • Four-way helical junctions in DNA molecules
  • Micromechanics of single supercoiled DNA molecules
  • Flexibility of nucleosomes on topologically constrained DNA
  • The mathematics of DNA structure, mechanics, and dynamics
  • Paradox regained: a topological coupling of nucleosomal DNA wrapping and chromatin fibre coiling
  • Statistical-mechanical analysis of enzymatic topological transformations in DNA molecules
  • List of workshop participants.