Oral Delivery of Macromolecular Drugs Barriers, Strategies and Future Trends /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Bernkop-Schnþrch, Andreas. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer US, 2009.
• Subjects: Medicine.; Toxicology.; Biochemistry.; Cytology.; Biomedicine.; Pharmacology/Toxicology.; Biochemistry, general.; Cell Biology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-0200-9

Due to a rapid development in biotechnology more and more macromolecular drugs such as therapeutic peptides, oligosaccharides and nucleic acids are entering the pharmaceutical arena representing unprecedented challenges from the drug delivery point of view. One of the likely greatest challenges is t...

Table of Contents:

• Enzymatic Barrier
• Gastrointestinal Mucus Gel Barrier
• The Absorption Barrier
• Strategies to Overcome the Enzymatic Barrier
• Low Molecular Mass Permeation Enhancers in Oraldelivery of Macromolecular Drugs
• Polymeric Permeation Enhancers
• Strategies to Overcome Efflux Pumps
• Multifunctional Polymeric Excipients in Oral Macromolecular Drug Delivery
• Nano- and Microparticles in Oral Delivery of Macromolecular Drugs
• Liposome-based Mucoadhesive Formulations for Oral Delivery of Macromolecules
• Strategies in Oral Immunization
• Oral Delivery of Nucleic Acid Drugs.