Handbook on Immunosenescence Basic Understanding and Clinical Applications /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Fulop, Tamas. (Editor), Franceschi, Claudio. (Editor), Hirokawa, Katsuiku. (Editor), Pawelec, Graham. (Editor)
• Format: Electronic
• Language: English
• Published: Dordrecht : Springer Netherlands, 2009.
• Subjects: Medicine.; Immunology.; Geriatrics.; Biomedicine.; Biomedicine general.; Geriatrics/Gerontology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4020-9063-9

Immunosenescence is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these chan...

Table of Contents:

• 1. Immunosenescence
• 2. Methods and models for studying immunosenescence
• 3. Cellular immunosenescence. 3.1 T cells. 3.2. B cells. 3.3 Neutrophils. 3.4 Antigen presenting cells. 3.5 NK and NKT cells. 3.6. Stem cells. 3.7. Genetics
• 4. Mechanisms 4.1. Receptors and signal transduction. 4.2 Mitochondria. 4.3 Proteasome. 4.4 Cytokines. 4.5 Neuro-endocrine-immune Network. 4.6 Thymus. 4.7. Inflammation
• 5. Clinical relevance in disease states. 5.1 Infection. 5.2 Autoimmunity. 5.3 Cancer. 5.4 Metabolic syndrome. 5.5. Neurodegenerative diseases. 5.6 Frailty. 5.7. Osteoporosis
• 6. Modulation. 6.1 Nutrition. 6.2. Lipids. 6.3. Vaccination. 6.4. Can interventions to influence immunosenescence succeed? Subject Index.