Mitochondria and Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Costello, Leslie. (Editor), Singh, Keshav. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York, 2009.
• Subjects: Medicine.; Oncology.; Medical laboratories.; Microbiology.; Cytology.; Biomedicine.; Cancer Research.; Medical Microbiology.; Molecular Medicine.; Cell Biology.; Biomedicine general.; Laboratory Medicine.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-0-387-84835-8

Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial meta...

Table of Contents:

• Warburg and the Warburg hypothesis
• The marriage of genomics, proteomics and intermediary metabolism: exciting and dangerous
• Oxidative phosphorylation: the link between metabolism and cancer
• Control of glycosis and oxidative phosphorylation in fast growing tumor cells
• The role of citrate metabolism in prostate malignancy and other tumors
• The role of mitochondria in the lipogenic
• Mitochondrial apoptosis pathways in cancer
• Mitochondrial tumor suppressors and neoplastic transformation
• Mitochondrial DNA mutations and tumorigenesis
• SDHD in parganglioma
• Mitochondria in hematogic maliagncies
• Mitochondria and oncocytomas
• Extracellular matrix signaling by mitochondria
• Mitochondria as biomarkers of cancer
• Mitochondria as target of cancer therapy.