The Kinetochore: From Molecular Discoveries to Cancer Therapy /

• Corporate Author: SpringerLink (Online service)
• Other Authors: De Wulf, Peter. (Editor), Earnshaw, William C. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York, 2009.
• Subjects: Medicine.; Oncology.; Human genetics.; Microbiology.; Medical virology.; Cytology.; Biomedicine.; Cancer Research.; Cell Biology.; Medical Microbiology.; Molecular Medicine.; Human Genetics.; Virology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-0-387-69076-6

Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "Th...

Table of Contents:

• Foreword
• The kinetochore and centromere: a historical perspective
• The mitotic and meiotic chromosome cycles in eukaryotes
• The centromere and neocentromere
• Human artificial centromeres
• Architectural and functional organization of kinetochores
• Holokinetochores
• Evolution of centromeres and kinetochores
• Structural and functional analysis of the spindle
• Kinetochore-spindle attachment
• Regulation of kinetochore activity
• Epigenetic regulation of kinetochore activity
• Regulation of spindle assembly checkpoint activity at the kinetochore
• Role of the kinetochore in meiosis
• The kinetochore cancer connection
• Kinetochore mutations in cancer tissues
• The kinetochore as an anti-cancer target.