Genome refactoring

The science of biology celebrates the discovery and understanding of biological systems that already exist in nature. In parallel, the engineering of biology must learn how to make use of our understanding of the natural world to design and build new useful biological systems. "Synthetic biolog...

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Bibliographic Details
Main Author: Kuldell, Natalie.
Other Authors: Lerner, Neal.
Format: Electronic
Language:English
Published: San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool Publishers, c2009.
Series:Synthesis lectures on synthetic biology (Online) ; # 1.
Subjects:
Online Access:View fulltext via EzAccess
Table of Contents:
  • Tools for genome engineering and synthetic biology
  • Introduction
  • DNA synthesis
  • Abstraction as a tool for managing and understanding biological complexity
  • Standards
  • Genome refactoring in the service of synthetic biology
  • References
  • Bacteriophage as templates for refactoring
  • Introduction
  • T7 background
  • Rebuilding T7
  • M13 background
  • Rebuilding M13
  • Reflection on M13 refactoring
  • References
  • Methods/teaching protocols for M13 reengineering
  • Introduction
  • Goals and outcomes for "simple" genetic engineering of M13
  • Goals and outcomes for refactoring M13
  • References
  • Writing and speaking as biological engineers
  • Introduction
  • Communications-intensive classes at MIT
  • Learning and the development of professional identity
  • Writing and speaking about synthetic biology
  • Understanding students' experiences with communicating synthetic biology
  • Conclusion
  • References
  • Summary and future directions
  • Summary
  • Future directions
  • References
  • Appendix A
  • Genome engineering essay assignment (Spring 2007)
  • Abstract
  • Introduction
  • Body: parts 1-3
  • Conclusions or summary
  • Appendix B
  • Part 1: rebuttal to editorial
  • Part 2: mini-business plan for the registry of standard biological parts
  • Appendix C
  • Section 1: vocabulary
  • Section 2: molecular biology.