Engineering the knee meniscus
The knee meniscus was once thought to be a vestigial tissue, but is now known to be instrumental in imparting stability, shock absorption, load transmission, and stress distribution within the knee joint. Unfortunately, most damage to the meniscus cannot be effectively healed by the body. Meniscus t...
| Main Author: | |
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| Other Authors: | |
| Format: | Electronic |
| Language: | English |
| Published: |
San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) :
Morgan & Claypool Publishers,
c2009.
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| Series: | Synthesis lectures on tissue engineering (Online) ;
# 1. |
| Subjects: | |
| Online Access: | View fulltext via EzAccess |
Table of Contents:
- Structure-function relationships of the knee meniscus
- Anatomy and development
- Anatomy of the knee meniscus
- Development of the knee meniscus
- Biochemical composition, structure, and function
- Regional variation
- Biochemical content
- Biomechanical properties and evaluation techniques
- Geometrical considerations
- Normal loading conditions
- Shock absorption
- Collagen organization
- Biphasic behavior
- Biomechanical evaluation
- Tension
- Compression
- Shear
- Cell types
- Cell classification
- Diversity of meniscus cells
- Cell synthetic properties
- Regional variation in synthetic profiles
- Mechanosensitivity of meniscus cells
- Pathophysiology and the need for tissue engineering
- Pathophysiology and injury
- Meniscus pathology
- Osteoarthritis and meniscal degeneration
- Tears of the meniscus
- Epidemiology of meniscus tears
- The meniscus healing problem
- Introduction
- Healing in the meniscus
- Characteristics of repair tissue
- Tissue engineering and historical perspectives
- Definition of tissue engineering
- Historical perspectives
- Functional tissue engineering and the meniscus
- Tissue engineering of the knee meniscus
- Bioreactors
- Introduction
- Direct compression
- Hydrostatic pressure
- Shear
- Ultrasound
- Combinations
- Application to meniscus engineering
- In vitro tissue engineering
- Introduction
- Cell source
- Growth factors
- Synthetic scaffolds
- Natural scaffolds
- Scaffold-free approaches
- In vivo tissue engineering
- Introduction
- Animal models
- Fibrin
- Synthetic scaffolds
- Natural scaffolds
- Current therapies and future directions
- Products and current therapies
- Products involving biological materials
- Other current therapies
- Design standards
- Determining design standards
- Primary standards
- Secondary standards
- Assessments for tissue engineered constructs
- Need for functional assessment
- Functionality index
- Variable considerations
- Bibliography.