Multiple Analyses in Clinical Trials Fundamentals for Investigators /

• Main Author: Moyé, Lemuel A. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York, 2003.
• Series: Statistics for Biology and Health,
• Subjects: Medicine.; Statistics.; Biomedicine.; Biomedicine general.; Statistics for Life Sciences, Medicine, Health Sciences.; Medicine/Public Health, general.
• Online Access: View fulltext via EzAccess

One of the most challenging issues for clinical trial investigators, sponsors, and regulatory officials is the interpretation of experimental results that are composed of the results of multiple statistical analyses. These analyses may include the effect of therapy on multiple endpoints, the assessm...

Table of Contents:

• Prologue
• Fundamentals of Clinical Trial Design
• Multiple Analyses and the Random Experiment
• The Lure and Complexity of Multiple Analyses
• Multiple Analyses and Multiple Endpoints
• to Multiple Dependent Analyses I
• Multiple Dependent Analyses II
• to Composite Endpoints
• Multiple Analyses and Composite Endpoints
• to Subgroup Analyses
• Subgroups II: Effect Domination and Controversy
• Subgroups III: Confirmatory Analyses
• Multiple Analyses and Multiple Treatment Arms
• Combining Multiple Analyses
• Conclusions: The Two-Front War.