Molecular Diversity in Drug Design

High-throughput screening and combinatorial chemistry are two of the most potent weapons ever to have been used in the discovery of new drugs. At a stroke, it seems to be possible to synthesise more molecules in a month than have previously been made in the whole of the distinguished history of orga...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Dean, Philip M. (Editor), Lewis, Richard A. (Editor)
Format: Electronic
Language:English
Published: Dordrecht : Springer Netherlands, 2002.
Subjects:
Online Access:View fulltext via EzAccess
Table of Contents:
  • Issues in Molecular Diversity and the Role of Ligand Binding Sites
  • Molecular Diversity in Drug Design. Application to High-speed Synthesis and High-Throughput Screening
  • Background Theory of Molecular Diversity
  • Absolute vs Relative Similarity and Diversity
  • Diversity in Very Large Libraries
  • Subset-Selection Methods For Chemical Databases
  • Molecular Diversity in Site-focused Libraries
  • Managing Combinatorial Chemistry Information
  • Design of Small Libraries for Lead Exploration
  • The Design of Small- and Medium-sized Focused Combinatorial Libraries.