Molecular Diversity in Drug Design
High-throughput screening and combinatorial chemistry are two of the most potent weapons ever to have been used in the discovery of new drugs. At a stroke, it seems to be possible to synthesise more molecules in a month than have previously been made in the whole of the distinguished history of orga...
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Other Authors: | , |
Format: | Electronic |
Language: | English |
Published: |
Dordrecht :
Springer Netherlands,
2002.
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Subjects: | |
Online Access: | View fulltext via EzAccess |
Table of Contents:
- Issues in Molecular Diversity and the Role of Ligand Binding Sites
- Molecular Diversity in Drug Design. Application to High-speed Synthesis and High-Throughput Screening
- Background Theory of Molecular Diversity
- Absolute vs Relative Similarity and Diversity
- Diversity in Very Large Libraries
- Subset-Selection Methods For Chemical Databases
- Molecular Diversity in Site-focused Libraries
- Managing Combinatorial Chemistry Information
- Design of Small Libraries for Lead Exploration
- The Design of Small- and Medium-sized Focused Combinatorial Libraries.