Antimicrobial peptides : discovery, design and novel therapeutic strategies /

• Format: eBook
• Language: English
• Published: Wallingford, Oxfordshire, UK : CABI, 2010.
• Series: Advances in molecular and cellular microbiology ; 18.
• Subjects: Peptide antibiotics.; Antimicrobial Cationic Peptides.; Anti-Infective Agents.; Drug Design.; Immunity, Innate.; Research.; Pesticides and Drugs; Control, (New March 2000); Pesticides and Drugs; Chemistry and Formulation, (New March 2000); Prion, Viral, Bacterial and Fungal Pathogens of Humans, (New March 2000); Animals.; Bacteria.; Plants.; Antimicrobial properties.; Bioinformatics.; Biophysics.; Classification.; Databases.; Drug development.; Medical research.; Mode of action.; Nomenclature.; Peptides.; Therapy.; Electronic books.
• Online Access: View fulltext via EzAccess

The purpose of this book is to provide a comprehensive account on current antimicrobial peptide research in two major directions. The first direction delineates the classic path for peptide development, ranging through identification, design, structure and mode of action studies. The second directio...

Table of Contents:

• A database view of naturally occurring antimicrobial peptides : nomenclature, classification, and amino acid sequence analysis / Guangshun Wang, Xia Li, and Michael Zasloff
• Lantibiotic-related research and the application thereof / Brian Healy, Jim O'Mahony, Colin Hill, Paul D. Cotter and R. Paul Ross
• Antimicrobial peptides in plants / Quentin Kaas, Jan-Christoph Westermann, Sónia Troeira Henriques and David J. Craik
• Database-aided prediction and design of novel antimicrobial peptides / Guangshun Wang
• Discovery of novel antimicrobial peptides using combinatorial chemistry and high-throughput screening / William C. Wimley
• Chemical mimics with systemic efficacy / Amram Mor
• Biophysical analysis of membrane-targeting antimicrobial peptides : membrane properties and the design of peptides specifically targeting gram-negative bacteria / Richard M. Epand and Raquel F. Epand
• Non-membrane targets of antimicrobial peptides : novel therapeutic opportunities? / Ju Hyun Cho and Sun Chang Kim
• Structural studies of antimicrobial peptides provide insight into their mechanisms of action / Guangshun Wang
• Lung infection : shifting the equilibrium towards the free and active form of human LL-37 and the design of alternative antimicrobial agents / Paul A. Janmey and Robert Bucki
• Role of vitamin D in the enhancement of antimicrobial peptide gene expression / John H. White and Ari J. Bitton
• Fine tuning host responses in the face of infection : emerging roles and clinical applications of host defence peptides / Matthew L. Mayer, Donna M. Easton, and Robert E. W. Hancock.