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130702s2013 ne | s |||| 0|eng d |
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|a 9789400768666
|9 978-94-007-6866-6
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|a 10.1007/978-94-007-6866-6
|2 doi
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|a RC261-271
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|a MJCL
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|a MED062000
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|a 614.5999
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|a Reichle, Albrecht.
|e editor.
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|a Evolution-adjusted Tumor Pathophysiology:
|b The Novel Language of Tumor Biology /
|c edited by Albrecht Reichle.
|h [electronic resource] :
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|a Dordrecht :
|b Springer Netherlands :
|b Imprint: Springer,
|c 2013.
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| 300 |
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|a X, 453 p. 95 illus., 87 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
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|a text file
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|a Preface.-I�Introduction.-Communication evolution pathophysiology: An endogenous conjunction Instead of an introduction.-II Combined modularized therapies for metastatic tumors: Pointing to central�problems of communication among systems participators in tumors -- Applied systems biology for the control of metastatic cancer: Therapeutic top-down strategy for targeting the tumors normativity -- Targeting the proangiogenic network in angiosarcomas: Biomodulatory therapy.-�Long-term results of combined modularized, immune-modulatory, angiostatic, and antiinflammatory therapy in systemically pre-treated multi-systems Langerhans cell histiocytosis.-�Redirecting and modulating rationalizations of tumor-immanent normative functions in castration-resistant prostate ancer.-III Social engineering: Biomodulation, either endogenously initiated or by implementation of non-normative boundary conditions -- Non-hierarchically organized operations in malignancies: Stromal dysfunction induces hematopoetic malignancies.-�Biomodulatory therapy approaches in renal clear cell carcinoma: A perspective.-�Proteome analysis identified the PPARc ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.IV�� The tumors normativity: Reconstructing and operationalizing starting��points for an evolution theory.-�The philosophical quest of a cancer cell: Redefining existentialism.-�The tumor s normativity: Normative structures, action norms and decision maxims as therapeutic targets for tumor therapy.-�Criticizable claims for the validity of communication acts in biological systems: Therapeutic implications in cancer.-V�Evolution theory.-�Evolution theory: Its practical relevance for understanding tumor�development and specifying tumor therapy -- Modularity, subjectivity, intersubjectivity and normativity: Clinically applicable operative benchmarks -- Turning upside down the mode of science to emphasize and harness the impact of environmental communicative events.�VI�� From genome- or organ-centric to rationalization-centric systematization of�tumors -- Purposive-rational tumor therapy: Exploiting the tumor s living world �for diversifying, specifying and personalizing tumor therapy -- Including rationalizations of tumor-associated normative notions in�pathophysiologic considerations: Communication-theoretical implications.-VII��Reconstruction of tumor-immanent normative functions, structures and decision maxims (hubs).-�Bridging a diagnostic and therapeutic gap: Selecting, assessing and categorizing tumor-associated normative notions.-�Personalizing tumor pathophysiology by diagnosing developmental problems in tumors with imaging techniques -- Biologic memory: Induction by metronomically administered combined modularized therapy.-�VIII�The tool of rationalizations constituting tumor-associated normative�notions:�The non-genomic counterpart of the tumor genome and therefore,�an important therapeutic target for diversifying palliative care -- Diversifying and specifying palliative care for patients with metastatic cancer by therapeutic implementation of non-normative boundary conditions -- Targeting a hallmark of cancer: Simultaneous inflammation and tumor control for palliative care in metastatic cancer.-IX� Novel clinical and pharmaceutical technology for bioengineering tumor�response.-�Combined modularized tumor therapy tumor biology and prognostic factors: Bioengineering tumor response.-X Objectifying the systems objects subjectivity in biological systems: A novel reification of the scientific picture about the objective world -- The systems objects subjectivity as scientific object. Index.
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|a Combined modularized therapies for metastatic cancer are pointing to central problems of communication among systems participators . A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and universal biomarkers concertedly address genetically based tumor heterogeneity.
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|a Medicine.
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| 650 |
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|a Oncology.
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| 650 |
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|a Pharmaceutical technology.
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| 650 |
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|a Biological models.
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| 650 |
1 |
4 |
|a Biomedicine.
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| 650 |
2 |
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|a Cancer Research.
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| 650 |
2 |
4 |
|a Biomedicine general.
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| 650 |
2 |
4 |
|a Systems Biology.
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| 650 |
2 |
4 |
|a Pharmaceutical Sciences/Technology.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9789400768659
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| 856 |
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|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-94-007-6866-6
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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